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Titolo:
EFFECT OF SUSTAINED STRETCH ON DISPERSION OF VENTRICULAR-FIBRILLATIONINTERVALS IN NORMAL RABBIT HEARTS
Autore:
BURTON FL; COBBE SM;
Indirizzi:
UNIV GLASGOW,DEPT MED CARDIOL GLASGOW G12 8QQ LANARK SCOTLAND
Titolo Testata:
Cardiovascular Research
fascicolo: 2, volume: 39, anno: 1998,
pagine: 351 - 359
SICI:
0008-6363(1998)39:2<351:EOSSOD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; MECHANOELECTRICAL FEEDBACK; CANINE HEARTS; VOLUME LOAD; REFRACTORINESS; ARRHYTHMIAS; FAILURE; REPOLARIZATION; EXCITABILITY; DILATATION;
Keywords:
ARRHYTHMIA; REFRACTORINESS; STRETCH; MAPPING; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F.L. Burton e S.M. Cobbe, "EFFECT OF SUSTAINED STRETCH ON DISPERSION OF VENTRICULAR-FIBRILLATIONINTERVALS IN NORMAL RABBIT HEARTS", Cardiovascular Research, 39(2), 1998, pp. 351-359

Abstract

Objective: To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. Methods: During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of localrefractoriness. Simultaneous measurement from multiple sites enables study of spatial aspects of changes in refractoriness. We studied the effects of stretch on the magnitude and dispersion of changes in VF interval in 10 isolated, Langendorff-perfused rabbit hearts using a flexible epicardial array containing 240 unipolar electrodes. The left ventricular pressure was increased from 0 to 40 mmHg by inflation of an intraventricular balloon during sustained VF. Results: The current threshold for VF induction fell from 64+/-11 mA to 43+/-11 mA (mean+/-SE, P<0.01) following ventricular dilatation. Mean VF interval at 0 mmHg was 79.8+/-1.3 ms and fell to 70.2+/-1.7 ms (P<0.01) at 40 mmHg. There was a corresponding increase in dispersion of VF interval (coefficientof variation) from 8.13+/-0.8 to 13.3+/-0.8 (P<0.01). There was regional heterogeneity in the areas of greatest reduction in VF interval, which varied between hearts. Following balloon inflation there was an increase in the number of activation waves. Conclusions: Acute ventricular dilatation produces spatially heterogeneous changes in refractoriness which would predispose to the maintenance of reentrant arrhythmias. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 21:18:56