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Titolo:
STRESS-INDUCED PULSE PRESSURE CHANGE PREDICTS WOMENS CAROTID ATHEROSCLEROSIS
Autore:
MATTHEWS KA; OWENS JF; KULLER LH; SUTTONTYRRELL K; LASSILA HC; WOLFSON SK;
Indirizzi:
UNIV PITTSBURGH,DEPT PSYCHIAT,SCH MED,3811 OHARA ST PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT SURG,SCH MED PITTSBURGH PA 15213 UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL PITTSBURGH PA 15213
Titolo Testata:
Stroke
fascicolo: 8, volume: 29, anno: 1998,
pagine: 1525 - 1530
SICI:
0039-2499(1998)29:8<1525:SPPCPW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; WALL THICKNESS; CARDIOVASCULAR-DISEASE; ARTERY DISEASE; MENTAL STRESS; RISK-FACTORS; HYPERTENSION;
Keywords:
ATHEROSCLEROSIS; CAROTID ARTERIES; RISK FACTORS; STRESS, PSYCHOLOGICAL; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Matthews et al., "STRESS-INDUCED PULSE PRESSURE CHANGE PREDICTS WOMENS CAROTID ATHEROSCLEROSIS", Stroke, 29(8), 1998, pp. 1525-1530

Abstract

Background and Purpose-Individuals who exhibit large increases in blood pressure and heart rate during mental stress may be at risk for accelerated atherosclerosis. This report evaluates the association between stress-induced hemodynamic responses and carotid atherosclerosis in 254 healthy postmenopausal women.Methods-The magnitude of change in blood pressure and heart rate from rest to public speaking and mirror image tracing, two stressful tasks, was measured. Average intima-media thickness (IMT) and focal plaque in the common carotid artery, bulb, and internal carotid artery were measured with the use of duplex ultrasonography on average 2.3 years later. Results-The average WIT was 0.77 mm, with a range of 0.60 to 1.37; 52.5% had at least one plaque. Correlational analysis showed that greater IMT was associated with greater pulse pressure change during mental stress (r=0.17, P<0.01). Statistical adjustments for possible confounders (age, hormone replacement therapy use, resting pulse pressure, smoking status, and triglyceride levels) did not alter the results. The plaque index was associated with greater pulse pressure change during the mirror image tracing task (oddsratio=1.47, P=0.01) for women with a plaque score of greater than or equal to 2 versus 1 or 0, adjusted for possible confounders. Conclusions-Mental stress-induced pulse pressure changes may influence the development of early atherosclerosis in the carotid artery of women. Widening of pulse pressure during stress, as well as at rest, may be a marker of compromised compliance in the vessel wall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:05:27