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Titolo:
PROINSULIN AND INSULIN CONCENTRATIONS IN RELATION TO CAROTID WALL THICKNESS - INSULIN-RESISTANCE-ATHEROSCLEROSIS-STUDY
Autore:
HAFFNER SM; DAGOSTINO R; MYKKANEN L; HALES CN; SAVAGE PJ; BERGMAN RN; OLEARY D; REWERS M; SELBY J; TRACY R; SAAD MF;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,7703 FLOYD CURL DR SAN ANTONIO TX 78284 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV CAMBRIDGE,DEPT CLIN BIOCHEM CAMBRIDGE ENGLAND NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033 TUFTS UNIV,SCH MED,DEPT RADIOL BOSTON MA 02111 UNIV COLORADO,SCH MED,DEPT PREVENT MED & BIOMETR DENVER CO 00000 KAISER PERMANENTE,DIV RES OAKLAND CA 00000 UNIV VERMONT,SCH MED,DEPT PATHOL BURLINGTON VT 05405 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED LOS ANGELES CA 90024
Titolo Testata:
Stroke
fascicolo: 8, volume: 29, anno: 1998,
pagine: 1498 - 1503
SICI:
0039-2499(1998)29:8<1498:PAICIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS; CORONARY-ARTERY DISEASE; ACTIVATOR INHIBITOR TYPE-1; B-MODE ULTRASOUND; GLUCOSE-TOLERANCE; NONDIABETIC SUBJECTS; SPLIT PROINSULIN; PLASMA-INSULIN;
Keywords:
ATHEROSCLEROSIS; INSULIN; PLASMINOGEN ACTIVATOR INHIBITOR-1; PROINSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Haffner et al., "PROINSULIN AND INSULIN CONCENTRATIONS IN RELATION TO CAROTID WALL THICKNESS - INSULIN-RESISTANCE-ATHEROSCLEROSIS-STUDY", Stroke, 29(8), 1998, pp. 1498-1503

Abstract

Background and Purpose-insulin resistance and hyperinsulinemia have been associated with atherosclerosis. Recent attention has focused on the possible role of proinsulin because most radioimmunoassays for insulin cross-react with proinsulin. Therefore, it is not known which of the two, insulin per se or proinsulin, is more strongly related to atherosclerosis. Methods-We examined the relation between fasting proinsulin, fasting split proinsulin, fasting and 2-hour insulin (after oral glucose load), and intima-media wall thickness (IMT) in the common carotid artery (CCA) and internal carotid artery (ICA) in 985 nondiabetic subjects from the Insulin Resistance Atherosclerosis Study, a multiethnic study of insulin resistance and atherosclerosis. Results-In the overall population, a weak but significant relation between proinsulin and CCA IMT was observed (r=0.07, P=0.029), However, the relation between proinsulin and IMT was stronger in Hispanics and non-Hispanic whites than in African Americans. In non-Hispanic whites and Hispanics, significant correlations between CCA and proinsulin (r=0.087) and betweenICA and proinsulin (r=0.101), split proinsulin (r=0.092), and fastinginsulin (r=0.087) were observed. The significant correlations became more attenuated (and nonsignificant) after adjustment for cardiovascular risk factors, especially plasminogen activator inhibitor-1 (PAI-1),Conclusions-The association between proinsulin and IMT, while weak, appears to be stronger than the association between insulin and IMT. Adjustment for PAI-1 markedly attenuated the association between proinsulin and IMT, suggesting a possible mediating role for PAI-1 in this association, It is possible that proinsulin may represent a marker of atherosclerosis rather than a causal factor for atherosclerosis, Studiesof the insulin resistance syndrome and atherosclerosis that use insulin as a surrogate for insulin resistance should consider the use of specific insulin assays as well as determination of proinsulin concentrations.

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Documento generato il 05/12/20 alle ore 20:02:23