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Titolo:
ASSOCIATION BETWEEN H-RAS MINISATELLITE AND COLORECTAL-CANCER RISK
Autore:
GOSSEBRUN S; SAUVAIGO S; DAVER A; LARRA F; KWIATKOWSKI F; BIGNON YJ; BERNARDGALLON D;
Indirizzi:
CTR PAUL PAPIN,LAB RADIOANAL,2 RUE MOLL F-49033 ANGERS 01 FRANCE CEA,CIS BIO INT F-38054 GRENOBLE FRANCE CTR JEAN PERRIN,INSERM,CRI 9402,MOL ONCOL LAB F-63011 CLERMONT FERRA 01 FRANCE CTR JEAN PERRIN,EA 2145 F-63011 CLERMONT FERRA 01 FRANCE
Titolo Testata:
Anticancer research
fascicolo: 4A, volume: 18, anno: 1998,
pagine: 2611 - 2616
SICI:
0250-7005(1998)18:4A<2611:ABHMAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT LENGTH POLYMORPHISMS; POLYMERASE CHAIN-REACTION; BREAST-CANCER; RARE ALLELES; VARIABLE NUMBER; DNA-SEQUENCE; LUNG-CANCER; VNTR LOCUS; FREQUENCY; MUTATIONS;
Keywords:
COLORECTAL CANCER; ALLELIC POLYMORPHISM; H-RAS MINISATELLITE; LOSS OF HETEROZYGOSITY; GENETIC INSTABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S. Gossebrun et al., "ASSOCIATION BETWEEN H-RAS MINISATELLITE AND COLORECTAL-CANCER RISK", Anticancer research, 18(4A), 1998, pp. 2611-2616

Abstract

Background: The H-ras locus has been suggested to play an important role in susceptibility to cancer. However, the results remain controversial. Methods: In order to elucidate the potential role of the H-ras locus in colorectal carcinogenesis, 142 colorectal tumors with matched normal samples were studied for genomic instability and loss of heterozygosity (LOH) and 143 healthy samples of white blood cell DNA were examined by PCR, for H-ras allelic polymorphism. Results: Nine percent of colorectal cancer patients constitutionally presented at least one rare allele versus 1.4% of healthy individuals (P = 0.0034). The risk of developing colorectal cancer increased significantly with the presence of rare H-ras alleles (odds ratio = 7.10 and 95% confidence interval = 1.92-26.35). The genotype associating one common allele and one rare allele was overrepresented in cancer patients (P < 0.01). No associations were observed between the rare alleles and tumor site or with the aggressiveness of cancer. Low frequencies of LOH (5%) and genetic instability (0.7%) at the H-ras locus were found in our colorectal cancer set. Conclusions: Consequently, the presence of uncommon alleles atthe H-ras locus appeared to be an informative genetic marker.

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Documento generato il 30/11/20 alle ore 05:37:35