Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROGNOSTIC VALUE OF P16(INK4A) EXPRESSION IN LUNG ADENOCARCINOMA
Autore:
VOLM M; KOOMAGI R; MATTERN J;
Indirizzi:
GERMAN CANC RES CTR,DEPT ONCOL DIAGNOST & THERAPY,NEUENHEIMER FELD 280 D-69120 HEIDELBERG GERMANY
Titolo Testata:
Anticancer research
fascicolo: 4A, volume: 18, anno: 1998,
pagine: 2309 - 2312
SICI:
0250-7005(1998)18:4A<2309:PVOPEI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE REGULATORS; GENE-PRODUCT; INACTIVATION; INHIBITION; TUMORS; CANCER; MTS2; RB;
Keywords:
PL6(INK4A); PROGNOSIS; ADENOCARCINOMAS OF THE LUNG; IMMUNOHISTOCHEMISTRY; CELL CYCLE PHASES; TAKE RATE IN NUDE MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Volm et al., "PROGNOSTIC VALUE OF P16(INK4A) EXPRESSION IN LUNG ADENOCARCINOMA", Anticancer research, 18(4A), 1998, pp. 2309-2312

Abstract

The analysis attempted to determine whether the expression of p16(INK4A) has prognostic relevance for patients with lung adenocarcinomas. For this purpose, immunohistochemistry was used to analyze 58 adenocarcinomas. Of the tumors investigated, 20 did not express p16(INK4A), while 38 yielded a positive staining result. Median survival time was shorter for patients with p16(INK4A) negative carcinomas than for those with p16(INK4A) positive tumors (47 vs. 79 weeks, P=0.11). The relativerisk for patients with p/61(INK4A) negative tumors was increased by afactor of 1.6 in comparison to positively stained tumors. There exists a direct correlation between the proportion of G0/G1 phase cells andthe p16(INK4A) expression. Additionally, there is an inverse relationship between S phases and p16(INK4A) expression. Furthermore, p16(INK4A) negative adenocarcinomas show more frequent growth in nude mice than p16(INK4A) - positive carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:15:13