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Titolo:
BIOLOGICAL EFFICACY AND SIGNAL-TRANSDUCTION THROUGH STAT PROTEINS OF RECOMBINANT DUCK INTERFERON IN DUCK HEPATITIS-B VIRUS-INFECTION
Autore:
HEUSS LT; HEIM MH; SCHULTZ U; WISSMANN D; OFFENSPERGER WB; STAEHELI P; BLUM HE;
Indirizzi:
UNIV HOSP FREIBURG,DEPT MED,HUGSTETTER STR 55 D-79106 FREIBURG GERMANY UNIV HOSP FREIBURG,DEPT MED D-79106 FREIBURG GERMANY INST MED MICROBIOL & HYG,DEPT VIROL D-79104 FREIBURG GERMANY
Titolo Testata:
Journal of General Virology
, volume: 79, anno: 1998,
parte:, 8
pagine: 2007 - 2012
SICI:
0022-1317(1998)79:<2007:BEASTS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-BETA RECEPTOR; TRANSCRIPTION FACTOR; TYROSINE PHOSPHORYLATION; GROWTH-FACTOR; GENE; ACTIVATION; EXPRESSION; INHIBITION; CLONING; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
L.T. Heuss et al., "BIOLOGICAL EFFICACY AND SIGNAL-TRANSDUCTION THROUGH STAT PROTEINS OF RECOMBINANT DUCK INTERFERON IN DUCK HEPATITIS-B VIRUS-INFECTION", Journal of General Virology, 79, 1998, pp. 2007-2012

Abstract

The aim of this study was to characterize the interferon induced intracellular signals in duck hepatocytes and to investigate the effects of duck interferon on virus replication in duck hepatitis B virus (DHBV) infected ducks. Interestingly, duck interferon was found to activateintracellular signal transduction pathways similar to those of its mammalian counterparts. An interferon stimulated gel shift activity likethat of gene factor 3 is induced, as well as serum inducible element binding factors homologous to serum inducible factor A (SIF-A), SIF-B and SIF-C. Duck interferon induced signal transducer and activator of transcription activation is not inhibited by DHBV infection of hepatocytes. DHBV infected ducks treated for 10 days with recombinant duck interferon show a decrease in viral DNA in hepatocytes, and in many cases disappearance of viraemia. These findings confirm the usefulness of the DHBV infection model for the study of human hepatitis B virus infection.

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Documento generato il 23/01/20 alle ore 03:44:55