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Titolo:
EFFECT OF BASAL EPICARDIAL TONE ON ENDOTHELIUM-INDEPENDENT CORONARY FLOW RESERVE MEASUREMENT
Autore:
HASDAI D; HOLMES DR; HIGANO ST; LERMAN A;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV INTERNAL MED ROCHESTER MN 55905
Titolo Testata:
Catheterization and cardiovascular diagnosis
fascicolo: 4, volume: 44, anno: 1998,
pagine: 392 - 396
SICI:
0098-6569(1998)44:4<392:EOBETO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATION; ULTRASOUND; ADENOSINE; VELOCITY; DOPPLER; NITROVASODILATORS; NITROGLYCERIN; VASODILATION; DYSFUNCTION; INVIVO;
Keywords:
ADENOSINE; ACETYLCHOLINE; CORONARY FLOW RESERVE; DOPPLER; CORONARY ARTERY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
D. Hasdai et al., "EFFECT OF BASAL EPICARDIAL TONE ON ENDOTHELIUM-INDEPENDENT CORONARY FLOW RESERVE MEASUREMENT", Catheterization and cardiovascular diagnosis, 44(4), 1998, pp. 392-396

Abstract

Increased basal epicardial tone may attenuate the coronary flow reserve (CFR) by causing vasodilatation of resistance vessels. We examined the effect of basal epicardial tone on the endothelium-independent CFRmeasurements in subjects with nonobstructive coronary disease. Patients underwent evaluation of endothelium-independent CFR using adenosine(18-36 mu g) and endothelium-dependent CFR using acetylcholine (10(-6)M-10(-4)M), both administered intracoronary, CFR to adenosine, presented as the ratio of Doppler flow velocities post- and pre-adenosine, was measured at baseline and after intracoronary nitroglycerin (200 mu g), Nitroglycerin increased the coronary artery diameter by 19.7 +/- 2.5%, and decreased the coronary vascular resistance from 3.0 +/- 0.2 mm Hg/ml/min to 1.8 +/- 0.1 mm Hg/ml/min (p < 0.0001), The response to adenosine at baseline and after nitroglycerin was similar (CFR ratio of 2.52 +/- 0.09 and 2.57 +/- 0.10, respectively, p = NS), The effect of nitroglycerin on the response to adenosine did not correlate with coronary endothelial function (r(2) = 0.06, p = 0.13), The basal epicardial tone does not affect CFR measurements in patients with angina and nonobstructive coronary disease. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 03:45:59