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Titolo:
CA2-INDUCED INHIBITION OF SODIUM-PUMP - NONCOMPETITIVE INHIBITION IN RESPECT OF MAGNESIUM AND SODIUM-CATIONS()
Autore:
BREIER A; SULOVA Z; VRBANOVA A;
Indirizzi:
SLOVAK ACAD SCI,INST MOL PHYSIOL & GENET,VLARSKA 5 BRATISLAVA 83334 SLOVAKIA SLOVAK ACAD SCI,INST CHEM BRATISLAVA 84238 SLOVAKIA
Titolo Testata:
General physiology and biophysics
fascicolo: 2, volume: 17, anno: 1998,
pagine: 179 - 188
SICI:
0231-5882(1998)17:2<179:CIOS-N>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
(NA+ + K+)-ATPASE; RED-BLOOD-CELLS; CA-DEPENDENT INHIBITION; CALCIUM-INHIBITION; NA,K-ATPASE; HYPOTHESIS; MODULATION; HEMOLYSATE;
Keywords:
(NA+/K+)-ATPASE; CA2+, BA2+, SR2+ INDUCED INHIBITION; COORDINATION BOUNDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Breier et al., "CA2-INDUCED INHIBITION OF SODIUM-PUMP - NONCOMPETITIVE INHIBITION IN RESPECT OF MAGNESIUM AND SODIUM-CATIONS()", General physiology and biophysics, 17(2), 1998, pp. 179-188

Abstract

Calcium inhibits the activity of the (Na+ /K+)-ATPase from dog kidneyin a dose-dependent manner. Other 2A group cations of the periodic table such as Sr2+ and Ba2+ were able to inhibit the ATPase activity butto a lesser degree. Any considerable competition between Ca2+ (Ba2+, Sr2+) ions and magnesium or sodium ions could not be detected using enzyme kinetic analysis. Thus, the above three inhibitory acting ions depress the ATPase activity of sodium pump by interaction with loci distant from the sodium and potassium binding sites. This suggests that the (Na+ /K+)-ATPase molecule contains an inhibitory acting binding sitefor calcium. This putative binding site could recognize magnesium ions as well as calcium, strontium and barium ions. The specificity of the binding site may describe herein be secured by a structure complementary to the coordination structure of Ca2+, Ba2+ and Sr2+ ions characterized by coordination number 8. Mg2+ ions can form coordination structure with a maximum coordination number 6, and do not interact specifically with this binding site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:10:16