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Titolo:
DOES CHRONIC SMOKING INFLUENCE FIBRINOLYTIC POTENTIAL IN TYPE-1 DIABETES-MELLITUS
Autore:
SIMPSON AJ; BOOTH NA; MOORE NR; GRAY RS;
Indirizzi:
UNIV EDINBURGH,SCH MED,RAYNE LAB,TEVIOT PL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND ST JOHNS HOSP,DEPT MED LIVINGSTON EH54 6PP SCOTLAND
Titolo Testata:
Diabetic medicine
fascicolo: 8, volume: 15, anno: 1998,
pagine: 683 - 687
SICI:
0742-3071(1998)15:8<683:DCSIFP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; LINKED IMMUNOSORBENT-ASSAY; CIGARETTE-SMOKING; CARDIOVASCULAR-DISEASE; HEMOSTATIC VARIABLES; INSULIN SENSITIVITY; PLATELET BEHAVIOR; VENOUS OCCLUSION; PLASMA; PAI-1;
Keywords:
TYPE 1 DIABETES; SMOKING; FIBRINOLYSIS; PLASMA; PLATELETS; TISSUE-TYPE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Simpson et al., "DOES CHRONIC SMOKING INFLUENCE FIBRINOLYTIC POTENTIAL IN TYPE-1 DIABETES-MELLITUS", Diabetic medicine, 15(8), 1998, pp. 683-687

Abstract

Tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were studied in 18 smokers and 18 closely matched non-smokers, all of whom had Type 1 diabetes mellitus (DM). None of the patients had advanced complications of diabetes. The t-PA and PAI-1 antigen levels were measured in plasma before and after venous occlusion, and were normal in Type 1 diabetes regardless of smoking status. Platelet PAI-1 levels were also measured and were found to be normal both in smokers and nonsmokers. In smokers with Type 1 DM, plasma PAI-1 was significantly correlated with triglycerides. The normal fibrinolytic potential found in smokers with diabetes contrasts starkly with the significantly elevated plasma PAI-1 reported in smokers without diabetes. In smokers, triglycerides may effect low levels of PAI-1 release intoplasma; this process may be significantly augmented in the presence of smoking-induced insulin resistance. The lack of endogenous insulin release in Type 1 diabetes may obviate the characteristic rise in plasma PAI-1 found in smokers who do not have diabetes. (C) 1998 John Wiley& Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:59:01