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Titolo:
MOLECULAR-CLONING AND CHARACTERIZATION OF A TUMOR REJECTION ANTIGEN FROM RAT HISTIOCYTOMA, AK-5
Autore:
MURALIKRISHNA T; BEGUM Z; SWAMY CVB; KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
DNA and cell biology
fascicolo: 7, volume: 17, anno: 1998,
pagine: 603 - 612
SICI:
1044-5498(1998)17:7<603:MACOAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MALIGNANT-MELANOMA; SPONTANEOUS IMMUNOLOGICAL REGRESSION; STRESS-INDUCED PROTEINS; CELL-SURFACE ANTIGENS; RECOGNITION; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Muralikrishna et al., "MOLECULAR-CLONING AND CHARACTERIZATION OF A TUMOR REJECTION ANTIGEN FROM RAT HISTIOCYTOMA, AK-5", DNA and cell biology, 17(7), 1998, pp. 603-612

Abstract

We have cloned and sequenced a tumor rejection antigen from a highly immunogenic rat histiocytoma, AK-5, Recombinant antigen induced an antibody response in syngeneic hosts, and the immunized animals showed significant resistance to AK-5 tumor challenge, where growth of the tumor was retarded, Autologous anti-AK-5 antibody, as well as the specificmonoclonal antibodies raised against whole AK-5 cells, recognized therecombinant protein, Similarly, recombinant antigen was able to neutralize antitumor antibody in a complement-mediated lysis assay. Antibodies raised against the fusion protein recognized a 60-kDa protein fromAK-5 cell extracts. A cDNA sequence analysis revealed significant homology with mouse thymus (81%), lymph node (83%), and human brain (71%)cDNAs; however, the function of these genes is not known, These observations suggest the recombinant protein to be a strong candidate for the tumor rejection antigen that is involved in the spontaneous regression of the AK-5 tumor in syngeneic hosts.

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Documento generato il 05/07/20 alle ore 10:24:09