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Titolo:
INTERCELLULAR CALCIUM SIGNALING AND GAP JUNCTIONAL COMMUNICATION IN ASTROCYTES
Autore:
GIAUME C; VENANCE L;
Indirizzi:
COLL FRANCE,INSERM,U114,11 PL MARCELIN F-75231 PARIS 05 FRANCE
Titolo Testata:
Glia
fascicolo: 1, volume: 24, anno: 1998,
pagine: 50 - 64
SICI:
0894-1491(1998)24:1<50:ICSAGJ>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GLIAL-CELLS; CULTURED ASTROCYTES; INOSITOL 1,4,5-TRISPHOSPHATE; CORTICAL ASTROCYTES; STRIATAL ASTROCYTES; CA2+ OSCILLATIONS; RAT ASTROCYTES; WAVES; GLUTAMATE;
Keywords:
CALCIUM WAVES; CONNEXIN; GLIAL CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
104
Recensione:
Indirizzi per estratti:
Citazione:
C. Giaume e L. Venance, "INTERCELLULAR CALCIUM SIGNALING AND GAP JUNCTIONAL COMMUNICATION IN ASTROCYTES", Glia, 24(1), 1998, pp. 50-64

Abstract

Two main characteristics of astrocytes are their elaborated intracellular calcium signaling and their high degree of intercellular communication mediated by gap junctional channels. In these cells a number of studies have contributed to demonstrate that the combination of these two properties provides a basis for a long-range signaling system within the brain. Intercellular calcium signaling, also termed calcium waves, allows astrocytes to communicate with each other and to interact with adjacent neurons. Most of the intra- and inter-cellular events involved in the initiation and propagation phases of this process has nowbeen identified. This sequence of events includes the permeability ofgap junction channels, which at the time-scale for calcium waves propagation, are likely permeated rather than closed by Ca2+ and/or related signaling molecules like IP3. In addition, in some studies an external component have been reported to participate to the propagation process. Finally, the control of the spread of intercellular calcium signaling has been demonstrated to occur at several levels including phospholipase C, IP3 receptors, intracellular Ca2+ stores, and cytoplasmic Ca2+ buffering. Accordingly, normal and pathological situations that affect one or several of these steps can be predicted to influence on astrocytic calcium waves. GLIA 24:50-64, 1998. (C) 1998 Wiiey-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:14:26