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Titolo:
GLUTAMATE RECEPTORS UNDERLYING EXCITATORY SYNAPTIC TRANSMISSION IN THE RATS LATERAL SUPERIOR OLIVE STUDIED IN-VITRO
Autore:
WU SH; FU XW;
Indirizzi:
CARLETON UNIV,INST NEUROSCI,LAB SENSORY NEUROSCI,LIFE SCI RES BLDG,1125 COLONEL BY DR OTTAWA ON K1S 5B6 CANADA
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 122, anno: 1998,
pagine: 47 - 59
SICI:
0378-5955(1998)122:1-2<47:GRUEST>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; ANTEROVENTRAL COCHLEAR NUCLEUS; D-ASPARTATE RECEPTORS; SOUND LOCALIZATION; INFERIOR COLLICULUS; ACOUSTIC CHIASM; NON-NMDA; IMMUNOCYTOCHEMICAL LOCALIZATION; PHYSIOLOGICAL-PROPERTIES; POSTSYNAPTIC CURRENTS;
Keywords:
AUDITORY SYSTEM; BINAURAL INTERACTION; SUPERIOR OLIVARY COMPLEX; IONOTROPIC GLUTAMATE RECEPTOR; METABOTROPIC GLUTAMATE RECEPTOR; PATCH CLAMP RECORDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Wu e X.W. Fu, "GLUTAMATE RECEPTORS UNDERLYING EXCITATORY SYNAPTIC TRANSMISSION IN THE RATS LATERAL SUPERIOR OLIVE STUDIED IN-VITRO", Hearing research, 122(1-2), 1998, pp. 47-59

Abstract

Glutamate receptors underlying synaptic excitation in the rat's lateral superior olive were studied by whole-cell patch clamp recordings ina brain slice preparation. Recordings from two morphological types ofcells, bipolar and multipolar, identified by intracellular labeling with biocytin, showed that there were no obvious differences in responses mediated or modulated by ionotropic and metabotropic receptors between these two types of neurons. The excitatory postsynaptic potentials(EPSPs) elicited by ipsilateral stimulation of the trapezoid body consisted of two components, An earlier component, which had faster rise time constant and decay time constant, was mediated by non-NMDA receptors. A later component, which had slower rise time and decay time constants, was mediated by NMDA receptors. Suprathreshold responses (action potentials), which arose from the early component, were always abolished by the non-NMDA antagonist, CNQX, but not by the NMDA antagonist,APV. These results suggest that both non-NMDA and NMDA receptors are present in LSO neurons, and that fast excitatory transmission in LSO is primarily mediated by non-NMDA receptors. The metabotropic glutamatereceptor agonists, t-ACPD and L-AP4 reduced the size of EPSPs evoked by stimulation of the ipsilateral trapezoid body in LSO neurons; the reductive action of t-ACPD was reversed by the antagonist, MCPG, indicating that metabotropic glutamate receptors, probably group II and III subtypes, can modulate excitatory synaptic transmission in LSO. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/09/20 alle ore 09:26:19