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Titolo:
ORGANIZATION OF THE EQUINE IMMUNOGLOBULIN HEAVY-CHAIN CONSTANT-REGIONGENES - III - ALIGNMENT OF C-MU, C-GAMMA, C-EPSILON AND C-ALPHA GENES
Autore:
WAGNER B; OVERESCH G; SHEORAN AS; HOLMES MA; RICHARDS C; LEIBOLD W; RADBRUCH A;
Indirizzi:
HANNOVER SCH VET MED,IMMUNOL UNIT,BISCHOFSHOLER DAMM 15 D-30173 HANNOVER GERMANY UNIV KENTUCKY,GLUCK EQUINE RES CTR LEXINGTON KY 40546 UNIV CAMBRIDGE,DEPT CLIN VET MED CAMBRIDGE CB3 0ES ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT PATHOL & MICROBIOL BRISTOL BS8 1TD AVONENGLAND GERMAN RHEUMATISM RES CTR BERLIN GERMANY
Titolo Testata:
Immunobiology
fascicolo: 1, volume: 199, anno: 1998,
pagine: 105 - 118
SICI:
0171-2985(1998)199:1<105:OOTEIH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY; FAMILY; RABBIT; IGA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
B. Wagner et al., "ORGANIZATION OF THE EQUINE IMMUNOGLOBULIN HEAVY-CHAIN CONSTANT-REGIONGENES - III - ALIGNMENT OF C-MU, C-GAMMA, C-EPSILON AND C-ALPHA GENES", Immunobiology, 199(1), 1998, pp. 105-118

Abstract

Previous restriction analysis of cloned equine DNA and genomic DNA ofequine peripheral blood mononuclear cells had indicated the existenceof one c epsilon, one c alpha and up to six c gamma genes in the haploid equine genome. The c epsilon and c alpha genes have been aligned on a 30 kb DNA fragment in the order 5' c epsilon-c alpha 3'. Here we describe the alignment of the equine c mu and c gamma genes by deletionanalysis of one IgM, four IgG and two equine light chain expressing heterohybridomas. This analysis establishes the existence of six cy genes per haploid genome. The genomic alignment of the c(H)-genes is 5' cmu // c gamma 1 // c gamma 2 // c gamma 3 // c gamma 4 // c gamma 5 // c gamma 6 // c epsilon-c alpha 3', naming the c gamma genes according to their position relative to c mu. For three of the c gamma genes the corresponding IgG isotypes could be identified as IgGa for c gamma 1, IgG(T) for c gamma 3 and IgGb for c gamma 4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:42:48