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Titolo:
EFFECT OF ASPIRIN ON PROTEIN-BINDING AND TISSUE DISPOSITION OF OLIGONUCLEOTIDE PHOSPHOROTHIOATE IN RATS
Autore:
AGRAWAL S; ZHANG XS; CAI QY; KANDIMALLA ER; MANNING A; JIANG ZW; MARCEL T; ZHANG RW;
Indirizzi:
HYBRIDON INC,620 MEM DR CAMBRIDGE MA 02139 UNIV ALABAMA BIRMINGHAM AL 35294 TMC DEV F-75116 PARIS FRANCE
Titolo Testata:
Journal of drug targeting
fascicolo: 4, volume: 5, anno: 1998,
pagine: 303 - 312
SICI:
1061-186X(1998)5:4<303:EOAOPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; H-3 LABELED OLIGONUCLEOTIDES; IN-VIVO STABILITY; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; ANTISENSE OLIGONUCLEOTIDES; PHARMACOKINETICS; BIODISTRIBUTION; METABOLISM; MICE; ALBUMIN;
Keywords:
OLIGONUCLEOTIDE; ASPIRIN; PHARMACOKINETICS; PHOSPHOROTHIOATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Agrawal et al., "EFFECT OF ASPIRIN ON PROTEIN-BINDING AND TISSUE DISPOSITION OF OLIGONUCLEOTIDE PHOSPHOROTHIOATE IN RATS", Journal of drug targeting, 5(4), 1998, pp. 303-312

Abstract

Pharmacokinetic studies of phosphorothioate oligodeoxynucleotides (PS-oligonucleotides) in animals show that following intravenous administration, PS-oligonucleotide clears out rapidly from the plasma and is distributed to majority of the organs. PS-oligonucleotides are bound toplasma proteins extensively. This study was aimed to determine the effect of aspirin, a commonly used drug, on pharmacokinetics of PS-oligonucleotides. In the present study, PS-oligonucleotide was administeredto rats that had received aspirin by gavage. Pharmacokinetic study shows that if PS-oligonucleotide was administered following aspirin administration in rats, a) plasma pharmacokinetic parameters (t(1/2 alpha)?, t(1/2 beta), AUC, etc.) had lower values, b) tissue disposition wasdifferent, and c) rate and route of elimination was affected in animals compared to rats receiving PS-oligonucleotide alone. This finding suggests that pharmacokinetics of PS oligonucleotides can be affected with certain class of drugs, which may have direct impact on biologicalactivity and safety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:52:33