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Titolo:
IMMUNOHISTOLOGIC FINDINGS AND ADHESION MOLECULE PATTERN IN PRIMARY PURE CUTANEOUS ROSAI-DORFMAN-DISEASE WITH XANTHOMATOUS FEATURES
Autore:
QUAGLINO P; TOMASINI C; NOVELLI M; COLONNA S; BERNENGO MG;
Indirizzi:
UNIV TURIN,DEPT MED & SURG SPECIALTIES,SECT DERMATOL 1,VIA CHERASCO 23 I-10126 TURIN ITALY UNIV TURIN,DEPT MED & SURG SPECIALTIES,SECT DERMATOL 1 I-10126 TURIN ITALY
Titolo Testata:
The American journal of dermatopathology
fascicolo: 4, volume: 20, anno: 1998,
pagine: 393 - 398
SICI:
0193-1091(1998)20:4<393:IFAAMP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUS HISTIOCYTOSIS; MASSIVE LYMPHADENOPATHY; IMMUNOPHENOTYPIC CHARACTERIZATION; DENDRITIC CELLS; MACROPHAGES; SKIN; INTEGRINS; XANTHOGRANULOMA; EXPRESSION; MONOCYTES;
Keywords:
HISTOPATHOLOGY; ROSAI-DORFMAN DISEASE; CUTANEOUS INVOLVEMENT; SINUS HISTIOCYTOSIS; SINUS HISTIOCYTOSIS CELL IMMUNOPHENOTYPE; XANTHOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
P. Quaglino et al., "IMMUNOHISTOLOGIC FINDINGS AND ADHESION MOLECULE PATTERN IN PRIMARY PURE CUTANEOUS ROSAI-DORFMAN-DISEASE WITH XANTHOMATOUS FEATURES", The American journal of dermatopathology, 20(4), 1998, pp. 393-398

Abstract

Skin involvement is common in sinus histiocytosis with massive lymphadenopathy (SH, Rosai-Dorfman disease), but pure cutaneous cases are rare. A 70-year-old woman presented with a 10-year history of large red-orange nodules and plaques on her upper arms, face, and buttocks, without evidence of lymphadenopathy or internal involvement. Distinctive histopathologic differences were observed according to the duration of the lesions. In recent lesions, the dermal infiltrate was mostly composed of sheets of characteristic SH cells; on the other hand, in long-lasting lesions, the presence of xanthomatous changes and prominent frbrosis, in keeping with the self-limited nature of this disease, raisesproblems of differential diagnosis with other xanthohistiocytic disorders. Immunophenotypic studies showed that the SH cells are S-100+ CD1a negative-activated macrophages, capable of lysosomal activity. The adhesion molecule pattern of SH cells (CD11b+, CD11c+, CD18+, CD62L+, and CD103+) was similar to that of circulating monocytes, suggesting their recent migration from the bloodstream.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:23:10