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Titolo:
EXPRESSION OF MESSENGER-RNA ENCODING NEUROTROPHINS AND NEUROTROPHIN RECEPTORS IN HUMAN GRANULOCYTES AND BONE-MARROW CELLS - ENHANCED NEUROTROPHIN-4 EXPRESSION INDUCED BY LTB4
Autore:
LAURENZI MA; BECCARI T; STENKE L; SJOLINDER M; STINCHI S; LINDGREN JA;
Indirizzi:
KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,DIV PHYSIOL CHEM 2 S-17177STOCKHOLM SWEDEN KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,DIV PHYSIOL CHEM 2 S-17177STOCKHOLM SWEDEN UNIV PERUGIA,DEPT CELLULAR & MOL BIOL I-06100 PERUGIA ITALY KAROLINSKA INST,DANDERYD HOSP,DEPT MED,DIV HEMATOL STOCKHOLM SWEDEN
Titolo Testata:
Journal of leukocyte biology
fascicolo: 2, volume: 64, anno: 1998,
pagine: 228 - 234
SICI:
0741-5400(1998)64:2<228:EOMENA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; COLONY-STIMULATING FACTOR; HUMAN LYMPHOCYTES-B; MOLECULAR-CLONING; MESSENGER-RNA; TISSUE DISTRIBUTION; TYROSINE KINASE; MAST-CELLS; RAT-BRAIN; TRK;
Keywords:
CHRONIC MYELOPROLIFERATIVE DISORDERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; TRKB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Laurenzi et al., "EXPRESSION OF MESSENGER-RNA ENCODING NEUROTROPHINS AND NEUROTROPHIN RECEPTORS IN HUMAN GRANULOCYTES AND BONE-MARROW CELLS - ENHANCED NEUROTROPHIN-4 EXPRESSION INDUCED BY LTB4", Journal of leukocyte biology, 64(2), 1998, pp. 228-234

Abstract

The expression of neurotrophin and neurotrophin receptor mRNAs in human granulocytes and bone marrow cells was examined using ribonuclease protection assay and reverse transcription -polymerase chain reaction. The granulocytes expressed mRNA coding for nerve growth factor (NGF),brain-derived neurotrophic factor (BDNF), and neurotrophin-4 (NT-4), but trot neurotrophin-3 (NT-3), Moreover, the inflammatory mediator leukotriene B-4 (LTB4) up-regulated the expression of NT-4 mRNA in granulocytes, but did not affect the expression of other neurotrophin mRNAs. Granulocytes generally lacked expression of mRNA coding for neurotrophin receptors. In contrast, human bone marrow cells consistently expressed mRNA for trkB (the BDNF and NT-4 receptor) and displayed variable expression of mRNA coding for trkA (the tyrosine kinase NGF receptor) and LNGFR (the low-affinity NGF receptor), whereas mRNA for trkC (the NT-3 receptor) was not expressed. Contrary to granulocytes, normal bone marrow cells generally expressed only low levels of mRNA encoding BDNF and NT-4. Expression of mRNA encoding NGF and NT-3 was not detected. However, significantly increased expression of BDNF mRNA was observed when bone marrow cells from patients with chronic myeloproliferative disorders (MPD) were analyzed. The results suggest that neurotrophins may act as granulocyte-derived effector molecules and that human bone marrow cells may be targets for these compounds, in particular BDNFand NT-4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:38:37