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Titolo:
FACTORS ASSOCIATED WITH ACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS AFTER END-STAGE RENAL-DISEASE
Autore:
SZETO CC; LI PKT; WONG TYH; LEUNG CB; LUI SF;
Indirizzi:
CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT MED SHATIN HONG KONG CHINESE UNIV HONG KONG,PRINCE WALES HOSP,DEPT MED SHATIN HONG KONG
Titolo Testata:
Journal of rheumatology
fascicolo: 8, volume: 25, anno: 1998,
pagine: 1520 - 1525
SICI:
0315-162X(1998)25:8<1520:FAWASL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL-DIALYSIS; CLINICAL COURSE; FAILURE; PROGNOSIS;
Keywords:
DIALYSIS; RENAL FAILURE; SYSTEMIC LUPUS ERYTHEMATOSUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Szeto et al., "FACTORS ASSOCIATED WITH ACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS AFTER END-STAGE RENAL-DISEASE", Journal of rheumatology, 25(8), 1998, pp. 1520-1525

Abstract

Objective, Activity of systemic lupus erythematosus (SLE) often declines after patients reach endstage renal disease (ESRD). However, extrarenal activity is not uncommon, especially during the first few years of dialysis. We reviewed the clinical course of SLE patients with ESRDtreated in our unit over the past 10 years, and tried to identify factors associated with postdialysis activity. Method. A retrospective study of Is patients with SLE (6 males) who received maintenance dialysis in our center from 1987 to 1996. Their clinical details, organ system manifestations, serologic profile, and treatment were reviewed. Patients with and without lupus flares after maintenance dialysis were compared.Results. Duration of followup was 43.4 +/- 32.7 months before dialysis and 33.8 +/- 28.9 months afterwards (4 hemodialysis, 14 peritoneal dialysis). Nine patients experienced 32 lupus postdialysis flares. The frequency was 0.63 flare per patient-year. Twenty flares (62.5%) developed within the first year of dialysis. Compared with the other 9patients who had no flares, patients with flares were younger (medianage at diagnosis of SLE 24 vs 33 years; median age when dialysis was initiated 26 vs 37 years; p < 0.05 both, Mann-Whitney U test) and morelikely to have history of seizure (6 in 9 vs 1 in 9 patients, p < 0.05, Fisher's exact test). There was a trend that patients with history of serositis and vasculitis were also associated with postdialysis activity, although this was not statistically significant. Conclusion. Postdialysis flare of SLE is not uncommon, particularly during first year of dialysis, Younger patients and those with history of seizure may have higher risk of postdialysis lupus flare. Careful followup is warranted, especially in potential transplant recipients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:47:14