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Titolo:
PRENATAL ADMINISTRATION OF PARA-CHLOROPHENYLALANINE RESULTS IN SUPPRESSION OF SEROTONERGIC SYSTEM AND DISTURBANCE OF SWIMMING MOVEMENTS IN NEWBORN RATS
Autore:
NAKAJIMA K; MATSUYAMA K; MORI S;
Indirizzi:
NATL INST PHYSIOL SCI,DEPT BIOL CONTROL SYST OKAZAKI AICHI 4448585 JAPAN NATL INST PHYSIOL SCI,DEPT BIOL CONTROL SYST OKAZAKI AICHI 4448585 JAPAN
Titolo Testata:
Neuroscience research
fascicolo: 2, volume: 31, anno: 1998,
pagine: 155 - 169
SICI:
0168-0102(1998)31:2<155:PAOPRI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; FREELY MOVING CATS; SPINAL-CORD; RAPHE NUCLEI; POSTNATAL-DEVELOPMENT; LOCOMOTOR MOVEMENTS; MONOAMINE NEURONS; NEONATAL RATS; BRAIN-STEM; ONTOGENY;
Keywords:
SEROTONERGIC SYSTEM; RAT; INTERLIMB COORDINATION; SWIMMING MOVEMENTS; POSTNATAL DEVELOPMENT; PARA-CHLOROPHENYLALANINE (PCPA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
K. Nakajima et al., "PRENATAL ADMINISTRATION OF PARA-CHLOROPHENYLALANINE RESULTS IN SUPPRESSION OF SEROTONERGIC SYSTEM AND DISTURBANCE OF SWIMMING MOVEMENTS IN NEWBORN RATS", Neuroscience research, 31(2), 1998, pp. 155-169

Abstract

Postnatal development of the spinal cord serotonergic (5-HT) system and of swimming movements were studied in newborn Sprague-Dawley rats, in which the serotonin level in the central nervous system was loweredin the prenatal period. For this purpose, para-chlorophenylalanine (PCPA) (300 mg/kg) was administered intraperitoneally to pregnant motherrats on day 8 of gestation, followed by a daily injection of PCPA (80mg/kg) from day 9 of gestation to delivery. The postnatal developmentof the 5-HT system in the spinal cord of the pups (PCPA-treated pups)born from the PCPA-administered mothers was markedly delayed during the period between PND 1 and PND 10 in comparison to that in the control pups born from healthy mothers. Postnatally, the control pups developed their swimming movements regularly through three distinct phases: forelimb dominant, forelimb and hindlimb well coordinated, hindlimb dominant. In contrast. in the PCPA-treated pups, swimming movements weredisorganized during the period in which the development of 5-HT system was delayed. However, between PND 17 and 22 in which the 5-HT systemdeveloped to that extent observed in the control pups, the pups eventually developed swimming movements as observed in the control pups. These results suggest that the disorganized developmental process of swimming movements in the PCPA-treated pups is due to the possible failure in the prenatal and postnatal development of the 5-HT system and itstarget system in the brain stem and the spinal cord. (C) 1998 Elsevier Science Inland Ltd. All rights reserved.

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Documento generato il 04/04/20 alle ore 08:52:22