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Titolo:
EXPRESSION OF DOPAMINE D1-RECEPTOR MESSENGER-RNA IN THE CAROTID-BODY OF ADULT-RABBITS, CATS AND RATS
Autore:
BAIRAM A; FRENETTE J; DAUPHIN C; CARROLL JL; KHANDJIAN EW;
Indirizzi:
CTR RECH,D0-717,10 RUE DE LESPINAY QUEBEC CITY PQ G1L 3L5 CANADA CTR HOSP UNIV QUEBEC,UNITE RECH PERINATOL QUEBEC CITY PQ G1L 3L5 CANADA CTR HOSP UNIV QUEBEC,UNITE RECH GENET HUMAINE & MOL QUEBEC CITY PQ G1L 3L5 CANADA JOHNS HOPKINS CHILDRENS CTR,DEPT PEDIAT PULMONOL BALTIMORE MD 00000
Titolo Testata:
Neuroscience research
fascicolo: 2, volume: 31, anno: 1998,
pagine: 147 - 154
SICI:
0168-0102(1998)31:2<147:EODDMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; AFFERENT PATHWAY; D1 RECEPTORS; NEURONS; CLONING; CHEMORECEPTORS; AGONISTS; HYPOXIA;
Keywords:
CAROTID BODY; SUPERIOR CERVICAL GANGLION; PETROSAL GANGLION; DOPAMINE; D1-RECEPTOR; D2-RECEPTOR; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A. Bairam et al., "EXPRESSION OF DOPAMINE D1-RECEPTOR MESSENGER-RNA IN THE CAROTID-BODY OF ADULT-RABBITS, CATS AND RATS", Neuroscience research, 31(2), 1998, pp. 147-154

Abstract

Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of adult rabbits, cats and rats. A DNA fragment of 611 bp of this receptor was first isolated from rabbit. The nucleic acid sequence of this fragment was found to be 84.5% identical to that of rat. This specific 611 bp fragment was used as a probe to detect, either by Northern analysis or by the reverse transcription-polymerase chain reaction, the dopamine D1-receptor mRNA. The results revealed the presence of dopamine D1-receptor transcript in the carotid body as well as in the petrosal ganglion and the superior cervical ganglion from the three animal models studied here. The physiological significance of dopamine D1-receptor expression in the carotid body is discussed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:45:51