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Titolo:
HUMORAL IMMUNE-RESPONSE TO MYCOBACTERIAL HEAT-SHOCK-PROTEIN (HSP)65 IN THE CEREBROSPINAL-FLUID OF NEURO-BEHCET PATIENTS
Autore:
TASCI B; DIRESKENELI H; SERDAROGLU P; AKMANDEMIR G; ERAKSOY M; SARUHANDIRESKENELI G;
Indirizzi:
ISTANBUL FAC MED,DEPT PHYSIOL TR-34390 CAPA TURKEY ISTANBUL FAC MED,DEPT NEUROL ISTANBUL TURKEY MARMARA MED SCH,DIV RHEUMATOL ISTANBUL TURKEY ISTANBUL FAC MED,DEPT PHYSIOL ISTANBUL TURKEY UNIV ISTANBUL,ELECTRONEUROPHYSIOL RES & APPLICAT CTR ISTANBUL TURKEY
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 113, anno: 1998,
pagine: 100 - 104
SICI:
0009-9104(1998)113:1<100:HITMH(>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; MULTIPLE-SCLEROSIS; DISEASE; ANTIBODIES; EXPRESSION; INVOLVEMENT; RECEPTOR; EPITOPE; ANTIGEN; BLOOD;
Keywords:
NEURO-BEHCETS DISEASE; CEREBROSPINAL FLUID; HEAT SHOCK PROTEIN 65;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Tasci et al., "HUMORAL IMMUNE-RESPONSE TO MYCOBACTERIAL HEAT-SHOCK-PROTEIN (HSP)65 IN THE CEREBROSPINAL-FLUID OF NEURO-BEHCET PATIENTS", Clinical and experimental immunology, 113(1), 1998, pp. 100-104

Abstract

Although systemic immune reactivity to 65-kD mycobacterial hsp65 (m-hsp65) has been shown previously in Behcet's disease (BD), local immuneresponse was not investigated. Mie studied anti-m-hsp65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 ED patients with cerebral parenchymal involvement (p-NBD), seven ED patientswith intracranial hypertension (ih-NBD), eight BD patients without central nervous system (CNS) involvement, 30 patients with multiple sclerosis (MS) and 24 patients with non-inflammatory CNS disorders (NIC). Significantly higher CSF IgG responses were detected in p-NBD patients(ELISA ratio 1.3 +/- 0.9) compared with NIC (0.7 +/- 0.4, P < 0.01). In p-NBD patients' IgG, IgM or IgA CSF anti-m-hsp65 positivity rate was 48% (12/25); this was significantly higher when compared with MS (3/30; P < 0.03) and NIC (3/24; P < 0.01). CSF anti-m-hsp65 IgG ratios correlated with the duration of ED (r = 0.4, P < 0.04) but not with the duration of neurological involvement. Serum IBM and IgA responses wereelevated in ih-NBD, suggesting a different type of involvement than p-NBD. These results implicate an increased local humoral response to m-hsp65 in the CSF of p-NBD patients, which might be related to the pathogenesis of neurological involvement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:20:19