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Titolo:
PATTERNS OF C-FOS EXPRESSION INDUCED BY FLUVOXAMINE ARE DIFFERENT AFTER ACUTE VS. CHRONIC ORAL-ADMINISTRATION
Autore:
VEENING JG; COOLEN LM; SPOOREN WJPM; JOOSTEN H; VANOORSCHOT R; MOS J; RONKEN E; OLIVIER B;
Indirizzi:
UNIV NIJMEGEN,FAC MED SCI,DEPT ANAT & EMBRYOL,POB 9101 NL-6500 HB NIJMEGEN NETHERLANDS SOLVAY DUPHAR BV,DEPT CNS PHARMACOL NL-1380 DA WEESP NETHERLANDS UNIV UTRECHT,FAC PHARM,DEPT PSYCHOPHARMACOL UTRECHT NETHERLANDS
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 8, anno: 1998,
pagine: 213 - 226
SICI:
0924-977X(1998)8:3<213:POCEIB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; DEXFENFLURAMINE-INDUCED ANOREXIA; PONTINE PARABRACHIAL AREA; RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; STRIA TERMINALIS; BED NUCLEUS; SOLITARY TRACT; EFFERENT PROJECTIONS;
Keywords:
FLUVOXAMINE; 5-HT RECEPTORS; NUCLEUS OF THE SOLITARY TRACT; LATERAL PARABRACHIAL NUCLEUS; BED NUCLEUS OF THE STRIA TERMINALIS; CENTRAL AMYGDALOID NUCLEUS; DEPRESSIVE ILLNESS; C-FOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Veening et al., "PATTERNS OF C-FOS EXPRESSION INDUCED BY FLUVOXAMINE ARE DIFFERENT AFTER ACUTE VS. CHRONIC ORAL-ADMINISTRATION", European neuropsychopharmacology, 8(3), 1998, pp. 213-226

Abstract

Fluvoxamine is a selective serotonin (5-HT) reuptake inhibitor (SSRI)with a broad spectrum of behavioral and therapeutic effects, e.g. in depressive illness. We used the expression of c-fos, after both acute and chronic oral administration of fluvoxamine in the rat, to study its immediate and long-term effects, in relation to the distribution of Galanin (GAL) and Vasoactive Intestinal Polypeptide (VIP). After acuteoral administration, most consistent increases were apparent in (parts of); the nucleus of the solitary tract, medial part; the lateral parabrachial nucleus, external part; the bed nucleus of the stria terminalis, dorsolateral part; and the central nucleus of the amygdala, lateral part. After chronic administration, distribution of Fos-IR was similar to acute administration, although numbers of Fos-IR neurons were no longer significantly different from control values. It is concluded that activation of 5-HT3-receptors in the caudal brainstem or gastro-intestinal afferents of the vagal nerve may Flay a role in the observedpattern of Fos-IR after fluvoxamine administration. The relationship with the antidepressant effects of fluvoxamine needs further investigations. (C) 1998 Elsevier Science B.V./ECNP.

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Documento generato il 01/04/20 alle ore 20:54:00