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Titolo:
ANTIAVERSIVE EFFECTS OF 5HT(2C) RECEPTOR AGONISTS AND FLUOXETINE IN AMODEL OF PANIC-LIKE ANXIETY IN RATS
Autore:
JENCK F; MOREAU JL; BERENDSEN HHG; BEES M; BROEKKAMP CLE; MARTIN JR; WICHMANN J; VANDELFT AML;
Indirizzi:
ROCHE,PRECLIN CNS RES,DIV PHARMA CH-4070 BASEL SWITZERLAND ORGANON,DEPT NEUROPHARMACOL NL-5340 BH OSS NETHERLANDS
Titolo Testata:
European neuropsychopharmacology
fascicolo: 3, volume: 8, anno: 1998,
pagine: 161 - 168
SICI:
0924-977X(1998)8:3<161:AEO5RA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIAQUEDUCTAL GRAY; M-CHLOROPHENYLPIPERAZINE; SEROTONIN AGONIST; 5-HT1C RECEPTORS; SB 200646A; META-CPP; DISORDER; BRAIN; ANTAGONIST; AVERSION;
Keywords:
ANXIETY; PANIC; ANIMAL MODEL; SEROTONIN; 5HT(2C); SSRI; BRAIN STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
F. Jenck et al., "ANTIAVERSIVE EFFECTS OF 5HT(2C) RECEPTOR AGONISTS AND FLUOXETINE IN AMODEL OF PANIC-LIKE ANXIETY IN RATS", European neuropsychopharmacology, 8(3), 1998, pp. 161-168

Abstract

Dose-dependent increases in threshold for operant fear/escape responses of rats submitted to aversive stimulation of the dorsolateral periaqueductal gray (dPAG) were recorded following intraperitoneal injection of three chemically unrelated but selective 5HT(2C) receptor agonists (Ro 60-0175, Org 12962 and Ro 60-0332) and fluoxetine. The decreasedsensitivity of rats to the acute panic-like aversion elicited by stimulation of this limbic periventricular region was detected at dosages devoid of impairing effects on the latencies needed for operant brain stimulation interruption. In this paradigm which has been validated asa simulation of acute anxiety with relevance to panic disorder, the selective activation of 5HT(2C) receptors by Ro 60-0175, Org 12962 or Po 60-0332 induces effects analogous to those observed following benzodiazepine receptor activation by antipanic agents such as clonazepam oralprazolam or following non-selective and indirect 5HT receptor activation by fluoxetine. Potency and efficacy of 5HT(2C) receptor agonistswere intermediate between those of clonazepam and fluoxetine, indicating authentic antiaversive properties and suggesting antipanic potential for these 5HT(2C) receptor agonists. In addition, these data suggest that the 5HT(2C) receptor subtype may play a major role in the therapeutic properties of selective serotonin reuptake inhibitors. It is also speculated that serotonin/benzodiazepine interactions existing in the brain may functionally involve the 5HT(2C) receptor subtypes and that the anxiogenic action reported under certain circumstances for 5HT mimetics are not mediated by 5HT(2C) receptor subtypes. (C) 1998 Elsevier Science B.V./ECNP.

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Documento generato il 25/02/20 alle ore 08:18:15