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Titolo:
AN ENTOURAGE EFFECT - INACTIVE ENDOGENOUS FATTY-ACID GLYCEROL ESTERS ENHANCE 2-ARACHIDONOYL-GLYCEROL CANNABINOID ACTIVITY
Autore:
BENSHABAT S; FRIDE E; SHESKIN T; TAMIRI T; RHEE MH; VOGEL Z; BISOGNO T; DEPETROCELLIS L; DIMARZO V; MECHOULAM R;
Indirizzi:
HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD,DAVID BLOOM CTR PHARM,EINKEREM CAMPUS IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,FAC MED,DEPT NAT PROD,DAVID BLOOM CTR PHARM IL-91120 JERUSALEM ISRAEL ISRAEL POLICE HEADQUARTERS,DIV IDENTIFICAT & FORENS SCI JERUSALEM ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL CNR,IST CHIM MOL INTERESSE BIOL I-80072 ARCO NAPLES ITALY CNR,IST CIBERNET I-80072 ARCO NAPLES ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 353, anno: 1998,
pagine: 23 - 31
SICI:
0014-2999(1998)353:1<23:AEE-IE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN CONSTITUENT; RECEPTOR; ANANDAMIDE; BINDS;
Keywords:
ANANDAMIDE; ENDOCANNABINOID; CANNABINOID RECEPTOR; 2-ARACHIDONOYL-GLYCEROL INACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S. Benshabat et al., "AN ENTOURAGE EFFECT - INACTIVE ENDOGENOUS FATTY-ACID GLYCEROL ESTERS ENHANCE 2-ARACHIDONOYL-GLYCEROL CANNABINOID ACTIVITY", European journal of pharmacology, 353(1), 1998, pp. 23-31

Abstract

2-Arachidonoyl-glycerol (2-Ara-G1) has been isolated from various tissues and identified as an endogenous ligand for both cannabinoid receptors, CB1 and CB2. Here we report that in spleen, as in brain and gut,2-Ara-G1 is accompanied by several 2-acyl-glycerol esters, two major ones being 2-linoleoyl-glycerol (2-Lino-G1) and 2-palmitoyl-glycerol (2-Palm-G1). These two eaters do not bind to the cannabinoid receptors,nor do they inhibit adenylyl cyclase via either CB1 or CB2; however, they significantly potentiate the apparent binding of 2-Ara-G1 and itsapparent capacity to inhibit adenylyl cyclase. Together these eaters also significantly potentiate 2-Ara-G1 inhibition of motor behavior, immobility on a ring, analgesia on a hot plate and hypothermia caused by 2-Ara-G1 in mice. 2-Lino-G1, but not 2-Palm-G1, significantly inhibits the inactivation of 2-Ara-G1 by neuronal and basophilic cells. These data indicate that the biological activity of 2-Ara-G1 can be increased by related, endogenous 2-acyl-glycerols, which alone show no significant activity in any of the tests employed, This effect ('entourage effect') may represent a novel route for molecular regulation of endogenous cannabinoid activity. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/10/20 alle ore 12:26:33