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Titolo:
THE EFFECT OF ELIPRODIL ON THE EVOLUTION OF A FOCAL CEREBRAL-ISCHEMIAIN-VIVO
Autore:
IBARROLA D; SEEGERS H; JAILLARD A; HOMMEL M; DECORPS M; MASSARELLI R;
Indirizzi:
HOP MICHALLON,INSERM,U438,BP 217,PAVILLON B F-38043 GRENOBLE 9 FRANCE HOP MICHALLON,INSERM,U438 F-38043 GRENOBLE 9 FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 352, anno: 1998,
pagine: 29 - 35
SICI:
0014-2999(1998)352:1<29:TEOEOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPARENT DIFFUSION-COEFFICIENT; D-ASPARTATE ANTAGONIST; ANTI-ISCHEMIC AGENTS; T2-WEIGHTED MRI; GYKI 52466; BLOOD-FLOW; RAT; POLYAMINE; EDEMA; IFENPRODIL;
Keywords:
CEREBRAL ISCHEMIA; MIDDLE CEREBRAL ARTERY OCCLUSION; DIFFUSION MAGNETIC RESONANCE IMAGING; ELIPRODIL; NMDA RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D. Ibarrola et al., "THE EFFECT OF ELIPRODIL ON THE EVOLUTION OF A FOCAL CEREBRAL-ISCHEMIAIN-VIVO", European journal of pharmacology, 352(1), 1998, pp. 29-35

Abstract

The purpose of the present study was to evaluate in vivo the effect of a non competitive antagonist of the NMDA receptor, eliprodil, on thesize of a focal ischaemic insult and on its temporal evolution in a rat model, using a spin-echo diffusion magnetic resonance imaging multislice technique. Rats were either injected with 1 mg/kg i.v. of eliprodil or with the vehicle only (placebo) 5 min after middle cerebral artery occlusion, or not injected (controls). Ten coronal slices were acquired every hour, up to 7 h after occlusion of the artery, and the volume of hyperintense signals was measured at each time point and for each animal. Diffusion magnetic resonance images revealed that the administration of eliprodil reduced significantly (by 50% or more) the volume of ischaemia, up to 7 h after occlusion, particularly in the cortexof the ipsilateral hemisphere. The results show the potential efficacy of eliprodil to reduce the cerebral ischaemic volume after arterial occlusion, thus confirming the interest of glutamate receptor antagonists in the treatment of ischaemia. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:17:28