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Titolo:
PHYSIOLOGICAL AND NEUROCHEMICAL ASPECTS OF CORTICOTROPIN-RELEASING FACTOR ACTIONS IN THE BRAIN - THE ROLE OF THE LOCUS-COERULEUS
Autore:
LEHNERT H; SCHULZ C; DIETERICH K;
Indirizzi:
UNIV HOSP MAGDEBURG,DEPT ENDOCRINOL & METAB,LEIPZIGER STR 44 D-39120 MAGDEBURG GERMANY
Titolo Testata:
Neurochemical research
fascicolo: 8, volume: 23, anno: 1998,
pagine: 1039 - 1052
SICI:
0364-3190(1998)23:8<1039:PANAOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FACTOR-LIKE IMMUNOREACTIVITY; FACTOR (CRF)-LIKE IMMUNOREACTIVITY; ANTERIOR-PITUITARY-CELLS; ADENYLATE-CYCLASE ACTIVITY; TYROSINE-HYDROXYLASE GENE; MESSENGER-RNA EXPRESSION; FACTOR-BINDING PROTEIN; FACTOR CRF RECEPTORS; RAT CEREBRAL-CORTEX;
Keywords:
CRF; CRF-RECEPTOR; LOCUS COERULEUS; CATECHOLAMINES; AUTONOMIC NERVOUS SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
175
Recensione:
Indirizzi per estratti:
Citazione:
H. Lehnert et al., "PHYSIOLOGICAL AND NEUROCHEMICAL ASPECTS OF CORTICOTROPIN-RELEASING FACTOR ACTIONS IN THE BRAIN - THE ROLE OF THE LOCUS-COERULEUS", Neurochemical research, 23(8), 1998, pp. 1039-1052

Abstract

Corticotropin-releasing factor (CRF) is both a major regulator of thehypothalamo-pituitary-adrenal (HPA) axis and the activity of the autonomic nervous system. Besides, it exerts numerous effects on other physiological functions such as appetite control, motor and cognitive behavior and immune function. The basis for these effects is constituted by its distribution in hypothalamic and extrahypothalamic brain areas,the latter being represented by limbic structures such as the centralnucleus of the amygdala or by brain stem neurons such as the locus coeruleus (LC) or nucleus of the solitary tract (NTS). The effects of CRF are mediated through recently described CRF-receptor subtypes, whosemolecular biology, biochemistry and pharmacological regulation are discussed in detail. In the second part of this review, we will focus onthe physiology of CRF-systems in the brain, with a particular emphasis on cardiovascular regulation, respiration, appetite control and stress-related behavior. Finally, the role of the locus coeruleus in the control of CRF-mediated behavioral activities is discussed. The interaction of noradrenergic and CRF-neurons clearly implies that CRF appearsto directly activate LC neurons in a stressful situation, thus ultimately coordinating the bodily response to a stressful stimulus.

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Documento generato il 28/11/20 alle ore 00:39:18