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Titolo:
ALTERATIONS IN THE FUNCTIONS OF THE RETICULOENDOTHELIAL AND PROTEASE-ANTIPROTEASE SYSTEMS AFTER INTRAPERITONEAL INJECTION OF ZYMOSAN IN RATS
Autore:
DENG XM; SUN ZW; LASSON A; WANG XD; ANDERSSON R;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN MALMO GEN HOSP,DEPT SURG S-21401 MALMO SWEDEN
Titolo Testata:
The European journal of surgery
fascicolo: 8, volume: 164, anno: 1998,
pagine: 605 - 615
SICI:
1102-4151(1998)164:8<605:AITFOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-ORGAN FAILURE; ACUTE EXPERIMENTAL PANCREATITIS; HYDROXYL RADICAL SCAVENGERS; BACTERIAL TRANSLOCATION; DIMETHYL-SULFOXIDE; N-ACETYLCYSTEINE; ANTITHROMBIN-III; MODEL; INFLAMMATION; INHIBITORS;
Keywords:
MULTIPLE ORGAN FAILURE; RETICULOENDOTHELIAL SYSTEM; MACROPHAGE; ZYMOSAN; N-ACETYL-L-CYSTEINE; DIMETHYL SULFOXIDE; PROTEASE INHIBITOR; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
X.M. Deng et al., "ALTERATIONS IN THE FUNCTIONS OF THE RETICULOENDOTHELIAL AND PROTEASE-ANTIPROTEASE SYSTEMS AFTER INTRAPERITONEAL INJECTION OF ZYMOSAN IN RATS", The European journal of surgery, 164(8), 1998, pp. 605-615

Abstract

Objective: To evaluate alterations in the function of the reticuloendothelial system (RES) and potential protective effects of pretreatmentwith the antioxidants: N-acetyl-L-cysteine (NAC) or dimethyl sulphoxide (DMSO), after intraperitoneal injection of zymosan (0.50 mg/g body weight) in rats. Design. Experimental study. Setting: University hospital, Sweden. Animals: 81 male Sprague-Dawley rats. Intervention: Intraperitoneal injection of either 4 ml saline or zymosan suspension (0.50mg/g body weight). One hour before the intraperitoneal injection, I mi of saline, or a solution of NAC (150 mg/kg) or DMSO (80 mg/kg) were given intravenously. Main outcome measures: Systemic arterial pressure, packed cell volume, concentrations of plasma proteins and plasma protease inhibitors, uptake of I-125-labelled Escherichia coli in organs,blood clearance and body uptake rate of radiolabelled E. coli, and blood flow in organs at 3, 6, and 12 hours after injection. Results: Theuptake of radiolabelled E. coli in the liver, spleen and lungs decreased significantly from 3 hours onwards after zymosan challenge (p < 0.05). Blood clearance and body uptake rate also decreased significantlyfrom 3 hours onwards (p < 0.05), but this did not correlate with the reduction in organ blood flow. Significant falls in plasma concentrations of prekallikrein (p < 0.01) and protease inhibitors (p < 0.05) suggested possible contact-phase activation and activation of the kallikrein-kinin and fibrinolytic system. Pretreatment with NAG, and to a less extent DMSO, significantly prevented these alterations in RES function. Conclusion: Zymosan induced an impairment in RES function that wasnot initially associated with a reduction in blood flow. Plasma proteolytic activity seems to be involved in the impaired RES function. Pretreatment with NAC or DMSO effectively improved RES function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:12:57