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Titolo:
ENDOTHELIN-INDUCED CONTRACTIONS IN PLACENTAL ARTERIES IS MEDIATED BY BOTH ETA-RECEPTORS AND ETB-RECEPTORS
Autore:
SAND AE; OSTLUND E; ANDERSSON E; FRIED G;
Indirizzi:
KAROLINSKA HOSP,DEPT WOMAN & CHILD HLTH,DIV OBSTET & GYNECOL S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP & INST,DEPT WOMEN & CHILD HLTH,DIV OBSTET & GYNAECOL STOCKHOLM SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 3, volume: 163, anno: 1998,
pagine: 227 - 234
SICI:
0001-6772(1998)163:3<227:ECIPAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VESSELS; B-RECEPTOR; HYPERTENSIVE PREGNANCIES; SELECTIVE AGONIST; BIG ENDOTHELIN-1; ET(B) RECEPTORS; POTENTIAL ROLE; BINDING-SITES; NITRIC-OXIDE; RAT AORTA;
Keywords:
BLOOD VESSELS; BQ-123; BQ-788; ENDOTHELIN; IRL-1620; NITRIC OXIDE; PLACENTA; VASOCONSTRICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Sand et al., "ENDOTHELIN-INDUCED CONTRACTIONS IN PLACENTAL ARTERIES IS MEDIATED BY BOTH ETA-RECEPTORS AND ETB-RECEPTORS", Acta Physiologica Scandinavica, 163(3), 1998, pp. 227-234

Abstract

We have examined the contractile response to the vasoconstrictor endothelin-l (ET-1) in uteroplacental arteries from normal pregnant women in the presence and absence of specific ET-receptor antagonists and agonists, and the vasodilator nitric oxide. Segments of placental arteries (n = 97) obtained from 37 placentas immediately after delivery weremounted in organ baths superfused with Krebs-Ringer solution at 37 degrees C. The tension was recorded isometrically and registered on a polygraph. We found that the placental artery segments responded to ET with a dose-dependent vasoconstriction. Half-maximal response was obtained at 2.6 x 10(-8) M. At 10(-7) M, the contractile response was 52% of the maximum KCI-response. The ET-1 induced contraction at 10(-7) M was inhibited by 74% after addition of the ETA -antagonist BQ-123 (10(-6) M), and by 58% by the ETB -antagonist BQ-788 (10(-6) M). Both BQ-123 and BQ-788 almost completely abolished the response to ET (10(-7) M). The selective ETB -agonist IRL-1620 also elicited vasoconstriction in the placental artery with a half maximal response at 8 x 10(-7) M. On a molar basis at 10(-7) M, the contraction by IRL-1620 as compared to ET was 30-fold lower. The contractile response of IRL-1620 (10(-6) M) was inhibited by 99% by BO-788 (10(-6) M). After pre-contraction of the placental arteries with ET-1 (10(-7) M), the vessels relaxed in response to the nitric oxide donor, nitroglycerin (10(-6) M). The present results show that ET-1 contracts placental arteries through both ETA- and ETB-receptor activation. Nitric oxide (10(-6) M) was able to relax more than halt of the initial ET-1 contraction. indicating that nitric oxide may be an important vasodilator in the placenta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:50:52