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Titolo:
INFLUENCE OF ARTERIAL BARORECEPTORS AND INTRACEREBROVENTRICULAR GUANABENZ ON SYNCHRONIZED RENAL NERVE ACTIVITY
Autore:
GRISK O; DIBONA GF;
Indirizzi:
ST GORANS SJUKHUS,RAIJA WALLENBORG DEPT PEDIAT S-11281 STOCKHOLM SWEDEN UNIV GREIFSWALD,DEPT PHYSIOL GREIFSWALD GERMANY UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 3, volume: 163, anno: 1998,
pagine: 209 - 218
SICI:
0001-6772(1998)163:3<209:IOABAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; SINOAORTIC-DENERVATED RATS; ANESTHETIZED CATS; RESPONSES; AMPLITUDE; MODEL;
Keywords:
ALPHA ADRENORECEPTORS; BAROREFLEX; RATS; SYMPATHETIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
O. Grisk e G.F. Dibona, "INFLUENCE OF ARTERIAL BARORECEPTORS AND INTRACEREBROVENTRICULAR GUANABENZ ON SYNCHRONIZED RENAL NERVE ACTIVITY", Acta Physiologica Scandinavica, 163(3), 1998, pp. 209-218

Abstract

The contributions of changes in the number of active fibres and the peak interval of synchronized neural discharges to arterial baroreflex regulated alterations in renal sympathetic nerve activity were examined in intact conscious rats. Stimulation of central nervous system at adrenoreceptors with intracerebroventricular guanabenz (10, 20, 40 mu g) was used to alter renal sympathetic nerve activity by a non-reflex mechanism in both intact and sinoaortic denervated (SAD) rats. Synchronized renal sympathetic nerve discharge was analysed with the sympathetic peak detection algorithm. When arterial pressure was increased from50 mmHg to 150 mmHg in intact rats, the peak height (number of simultaneously active fibres) of synchronized discharges decreased in a sigmoidal fashion while the peak interval remained unchanged. Guanabenz produced a dose dependent inhibition of renal sympathetic nerve activitydue to both a decrease in peak height and an increase in peak interval of synchronized discharges in both intact and SAD rats. Arterial baroreflex mediated changes in renal sympathetic nerve activity are due to changes in the number of simultaneously active nerve fibres. Centralnervous system alpha(2) adrenoreceptor stimulation decreases renal sympathetic nerve activity by decreasing the number of active fibres andincreasing the peak interval, acting on additional neural pathways not involved in buffering acute arterial pressure changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:48:20