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Titolo:
CLINICAL-APPLICATION OF THE MEASUREMENT OF CORD PLASMA LACTATE AND PYRUVATE IN THE ASSESSMENT OF HIGH-RISK NEONATES
Autore:
CHOU YH; YAU KIT; WANG PJ;
Indirizzi:
CHANG GUNG CHILDRENS HOSP,DIV NEONATOL,5 FU SHING ST TAYUAN TAIWAN CHANG GUNG MED COLL,DEPT PEDIAT TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED TAIPEI TAIWAN
Titolo Testata:
Acta paediatrica
fascicolo: 7, volume: 87, anno: 1998,
pagine: 764 - 768
SICI:
0803-5253(1998)87:7<764:COTMOC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERINATAL ASPHYXIA; CEREBRAL-PALSY; BRAIN-DAMAGE; TERM; ENCEPHALOPATHY; ACIDOSIS; INFANTS; BIRTH; BLOOD; DEATH;
Keywords:
HIGH-RISK NEONATES; LACTATE; PYRUVATE; LACTATE/PYRUVATE RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Chou et al., "CLINICAL-APPLICATION OF THE MEASUREMENT OF CORD PLASMA LACTATE AND PYRUVATE IN THE ASSESSMENT OF HIGH-RISK NEONATES", Acta paediatrica, 87(7), 1998, pp. 764-768

Abstract

Lactate levels in combination with lactate/pyruvate (L/P) ratio have been used to measure altered cellular redox states. We measured the cord plasma lactate levels and L/P ratios in 70 normal neonates (40 full-term and 30 preterm neonates) to set up the normal (control) ranges. The control cord plasma lactate levels and LIP ratios were 2660 [700 (SD)] mu mol/l, 16 (3) in full-term neonates and 2750 (740) mu mol/l, 17 (3) in preterm neonates, respectively. We also measured the lactate levels and LIP ratios in the high-risk full-term (n = 23) and preterm (n = 35) neonates, the results were 4500 (2600) mu mol/l, 19 (13), and5100 (2700) mu mol/l, 26 (12), respectively. With the aid of elevatedlactate levels and L/P ratios, the occurrence of neonatal encephalopathy can be predicted with a sensitivity of 100% and a specificity of 94.5% in this patient group. Tn our study, the six cases with abnormal neurodevelopment at 6-9 months of age all had both elevated lactate levels and WP ratios at birth. We conclude that the measurement of lactate levels in combination with L/P ratios is a useful quantitative toolin assessing the existence and severity of perinatal hypoxia in the high-risk neonates.

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Documento generato il 27/01/20 alle ore 01:30:40