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Titolo:
CREVICULAR FLUID LEVEL OF BETA-GLUCURONIDASE IN RELATION TO CLINICAL PERIODONTAL PARAMETERS AND PUTATIVE PERIODONTAL PATHOGENS IN EARLY-ONSET PERIODONTITIS
Autore:
ALBANDAR JM; KINGMAN A; LAMSTER IB;
Indirizzi:
UNIV BERGEN,FAC DENT,SECT PERIODONTOL,ARSTADVEIEN 17 N-5009 BERGEN NORWAY NIDR BETHESDA MD 20892 COLUMBIA UNIV,SCH DENT & ORAL SURG,DIV PERIODONT NEW YORK NY 10027
Titolo Testata:
Journal of clinical periodontology
fascicolo: 8, volume: 25, anno: 1998,
pagine: 630 - 639
SICI:
0303-6979(1998)25:8<630:CFLOBI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED JUVENILE PERIODONTITIS; ADULT PERIODONTITIS; SUBGINGIVAL PLAQUE; ENZYME-ACTIVITY; ATTACHMENT LOSS; ADOLESCENTS; DISEASE; MULTICENTER; LESIONS; CARIES;
Keywords:
ADOLESCENTS; PERIODONTAL DISEASES, DIAGNOSIS; PERIODONTAL DISEASES, EARLY-ONSET; PERIODONTITIS, IMMUNOLOGY; NEUTROPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Albandar et al., "CREVICULAR FLUID LEVEL OF BETA-GLUCURONIDASE IN RELATION TO CLINICAL PERIODONTAL PARAMETERS AND PUTATIVE PERIODONTAL PATHOGENS IN EARLY-ONSET PERIODONTITIS", Journal of clinical periodontology, 25(8), 1998, pp. 630-639

Abstract

Analysis of beta-glucuronidase (beta G) in the gingival crevicular fluid (GCF) provides an indication of neutrophil influx into the crevicular environment. The aim of this study was to test the hypotheses that: (1) beta G is significantly elevated in individuals with early-onsetperiodontitis (EOP) and that beta G activity correlates with disease severity; and (2) beta G level may reflect the local bacterial challenge in the gingival crevice. The study subjects consisted of a sub-sample of individuals examined in the National Survey of Oral Health of United States Children, which was undertaken during the 1986/87 school year. A total of 249 individuals were selected based on presence or absence of clinical attachment loss at baseline. The individuals were examined a second time 6 years later and the clinical attachment loss wasassessed, and subgingival plaque and GCF were collected. The subjectswere classified into 3 types of EOP and a control group. beta G activity in the GCF and the levels of 7 putative micro-organisms in the pocket were assessed. The generalized EOP group had the highest beta G activity, followed by the localized and incidental EOP groups, and the controls, respectively. There was a significant increase in beta G activity with the increase in probing depth, Also, sites with bleeding on probing had a significantly higher beta G activity than sites without bleeding. However, the effect of gingival inflammation on beta G activity was more evident in the generalized and localized EOP groups. Sites harboring high levels of one or more of the micro-organisms tended to have high beta G activity. There were moderate differences between the organisms with respect to their effect on beta G activity, but sites with high numbers of Porphyromonas gingivalis, Prevotella intermedia, or Treponema denticola also had the highest beta G activity. The present findings suggest that beta G activity in GCF from patients with EOP can be of value in the early identification of individuals at higher risk of developing EOP. The findings also suggest that host mechanisms leading to higher beta G activity in EOP represent systemic responses and are only partly related to the presence of local factors at thesite-level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:41:28