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Titolo:
MULTIPLE GENOTOXICITY BIOMARKERS IN FISH EXPOSED IN-SITU TO POLLUTED RIVER WATER
Autore:
DEFLORA S; VIGANO L; DAGOSTINI F; CAMOIRANO A; BAGNASCO M; BENNICELLI C; MELODIA F; ARILLO A;
Indirizzi:
UNIV GENOA,INST HYG & PREVENT MED,VIA PASTORE 1 I-16132 GENOA ITALY UNIV GENOA,INST ZOOL I-16132 GENOA ITALY CNR,WATER RES INST I-20133 MILAN ITALY
Titolo Testata:
MUTATION RESEARCH
fascicolo: 3, volume: 319, anno: 1993,
pagine: 167 - 177
SICI:
0027-5107(1993)319:3<167:MGBIFE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLE PAROPHRYS-VETULUS; RAINBOW-TROUT; AROMATIC-COMPOUNDS; MUTAGENICITY TEST; PUGET-SOUND; INDUCTION; LIVER; BILE; METABOLITES; BENZO)A>PYRENE;
Keywords:
RIVER POLLUTION; FISH (ONCORHYNCHUS-MYKISS); BILE MUTAGENICITY; ENZYME INDUCTION; LIVER METABOLISM; MICRONUCLEUS TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Deflora et al., "MULTIPLE GENOTOXICITY BIOMARKERS IN FISH EXPOSED IN-SITU TO POLLUTED RIVER WATER", MUTATION RESEARCH, 319(3), 1993, pp. 167-177

Abstract

Specimens of rainbow trout (Oncorhynchus mykiss) were either kept in an aquarium under laboratory conditions or caged in the River Po (Northern Italy), upstream or downstream the confluence with the River Lambro, a small yet heavily polluted tributary. Genotoxicity biomarkers, evaluating the internal dose or early biological effects, were monitored after 7, 15 and 30 days of in situ exposure. With the exception of aslight increase of aminopyrine-N-demethylase and uridine-5'-diphospho-glucuronosyl-transferase, no significant effect was produced in fish kept upstream the River Lambro, as compared to control fish kept in the aquarium. In contrast, the responsibility of this tributary in carrying sublethal doses of both genotoxic agents and enzyme inducers into the main river was proved by the significant occurrence of early biological alterations in fish caged downstream. In fact, (a) bile extractscontained frameshift mutagens requiring metabolic activation, with a prevalence of liposoluble components after a short exposure, followed by a time-related increase of conjugated components, in minor part with glucuronic acid; (b) the monooxygenases aminopyrine-N-demethylase, uridine-5'-diphospho-glucuronosyl-transferase and, with sharp differences, arylhydrocarbon hydroxylase and 7-ethoxyresorufin-0-deethylase were enhanced in liver microsomal fractions; (c) the liver cytosolic fractions had an enhanced ability to convert 3-amino-1-methyl-5H-pyrido(4,3)indole into mutagenic metabolites in S. typhimurium; (d) cytogeneticdamage was demonstrated by an increased frequency of micronuclei in peripheral blood erythrocytes.

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Documento generato il 21/09/20 alle ore 02:08:23