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Titolo:
DETERMINANTS OF SPECIFICITY IN TGF-BETA SIGNAL-TRANSDUCTION
Autore:
CHEN YG; HATA A; LO RS; WOTTON D; SHI YG; PAVLETICH N; MASSAGUE J;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,CELL BIOL PROGRAM,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,CELL BIOL PROGRAMNEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST,CELLULAR BIOCHEM & BIOPHYS PROGRAM NEW YORK NY 10021
Titolo Testata:
Genes & development
fascicolo: 14, volume: 12, anno: 1998,
pagine: 2144 - 2152
SICI:
0890-9369(1998)12:14<2144:DOSITS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; RECEPTOR COMPLEX; TRANSCRIPTIONAL RESPONSES; MAD PROTEINS; I RECEPTORS; ACTIVIN; DPC4; GENE; SUPERFAMILY; DOWNSTREAM;
Keywords:
TGF-BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; BMP PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
Y.G. Chen et al., "DETERMINANTS OF SPECIFICITY IN TGF-BETA SIGNAL-TRANSDUCTION", Genes & development, 12(14), 1998, pp. 2144-2152

Abstract

Signal transduction by the TGF-beta family involves sets of receptor serine/threonine kinases, Smad proteins that act as receptor substrates, and Smad-associated transcription factors that target specific genes. We have identified discrete structural elements that dictate the selective interactions between receptors and Smads and between Smads andtranscription factors in the TGF-beta and BMP pathways. A cluster of four residues in the L45 loop of the type I receptor kinase domain, and a matching set of two residues in the L3 loop of the Smad carboxy-terminal domain establish the specificity of receptor-Smad interactions. A cluster of residues in the highly exposed alpha-helix 2 of the Smadcarboxy-terminal domain specify the interaction with the DNA-binding factor Fast1 and, as a result, the gene responses mediated by the pathway. By establishing specific interactions, these determinants keep the TGF-beta and BMP pathways segregated from each other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:53:15