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Titolo:
PROSTAGLANDIN E-2 INHIBITS APOPTOSIS IN HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES - ROLE OF INTRACELLULAR CYCLIC-AMP LEVELS
Autore:
OTTONELLO L; GONELLA R; DAPINO P; SACCHETTI C; DALLEGRI F;
Indirizzi:
UNIV GENOA,SCH MED,DEPT INTERNAL MED,MED CLIN 1,VIALE BENEDETTO 25,6 I-16132 GENOA ITALY
Titolo Testata:
Experimental hematology
fascicolo: 9, volume: 26, anno: 1998,
pagine: 895 - 902
SICI:
0301-472X(1998)26:9<895:PEIAIH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; ENDOGENOUS ENDONUCLEASE ACTIVATION; COLONY-STIMULATING FACTOR; THYMOCYTE APOPTOSIS; RECEPTOR COMPLEX; IN-VITRO; SURVIVAL; CAMP; INFLAMMATION; AGENTS;
Keywords:
NEUTROPHILS; APOPTOSIS; CYCLIC AMP; ELEVATING AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
L. Ottonello et al., "PROSTAGLANDIN E-2 INHIBITS APOPTOSIS IN HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES - ROLE OF INTRACELLULAR CYCLIC-AMP LEVELS", Experimental hematology, 26(9), 1998, pp. 895-902

Abstract

Human neutrophilic polymorphonuclear leukocytes (neutrophils) are terminally differentiated cells that die by undergoing apoptosis. At present, the intracellular pathways governing this process are only partially known. In particular, although the adenylate cyclase-dependent generation of cyclic AMP (cAMP) has been implicated in the triggering of apoptosis in lymphoid cells, the role of the intracellular cAMP pathway in neutrophil apoptosis remains controversial. In the present study,we found that two cAMP-elevating agents, prostaglandin E-2 (PGE(2)) and the phosphodiesterase type IV inhibitor RO 20-1724, inhibit neutrophil apoptosis without inducing cell necrosis. When administered in combination, PGE, and RO 20-1724 displayed additive effects. Moreover, neutrophil apoptosis was inhibited by a membrane-permeable analog of cAMP, dibutyryl-cAMP, in a dose-dependent manner. Finally, treatment of neutrophils with the protein kinase A inhibitor H-89 prevented PGE,and RO 20-1724-induced inhibition of cell apoptosis. In conclusion, takinginto account that PGE(2) and other cAMP-elevating agents are well known downregulators of neutrophil functions, our results suggest that conditions favoring a state of functional rest, such as intracellular cAMP elevation, prolong the life span of neutrophils by delaying apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:01:11