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Titolo:
ROLE OF GABA IN THE ACTIONS OF ETHANOL IN RATS SELECTIVELY BRED FOR ETHANOL SENSITIVITY
Autore:
LIU Y; DEITRICH RA;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,DEPT PHARMACOL C236,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,ALCOHOL RES CTR DENVER CO 80262
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 60, anno: 1998,
pagine: 793 - 801
SICI:
0091-3057(1998)60:4<793:ROGITA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; SHORT-SLEEP MICE; ACTIVATED CHLORIDE CHANNELS; GENERAL ANESTHETIC PROPOFOL; LONG-SLEEP; GABAERGIC TRANSMISSION; GENETIC-DIFFERENCES; RECEPTOR SUBTYPES; CEREBRAL-CORTEX; EXVIVO BINDING;
Keywords:
ETHANOL; SELECT LINES; BEHAVIORAL RESPONSE; GABA(A) RECEPTOR; CHLORIDE UPTAKE; FLUNITRAZEPAM; TBPS; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
Y. Liu e R.A. Deitrich, "ROLE OF GABA IN THE ACTIONS OF ETHANOL IN RATS SELECTIVELY BRED FOR ETHANOL SENSITIVITY", Pharmacology, biochemistry and behavior, 60(4), 1998, pp. 793-801

Abstract

Rats from the Ni/Nih heterogeneous stock have been selectively bred for high (HAS) or low (LAS) initial sensitivity to injected ethanol as measured by duration of the loss of the righting reflex. The selectionfor ethanol sensitivity in these lines apparently has reached a maximum. These lines are useful to elucidate the central nervous system mechanisms of the genetic differences between the lines and also provide clues to the mechanisms of ethanol's action. We have found that: 1) ethanol, etomidate, and ketamine but not propofol produce different sleep times and brain levels of the drug on awakening between these two lines; 2) only ethanol, etomidate, and ketamine produced significant differences between the HAS and LAS rats in GABA-mediated stimulation of chloride uptake into brain microsacs; 3) GABA, propofol, and etomidatedecreased the K-d for flunitrazepam binding to whole-brain membranes but equally in both lines. Neither ethanol nor ketamine had an effect;4) only GABA, ethanol, and etomidate increased the K-d for TBPS binding and only GABA decreased B-max of TBPS binding. As with the previousselection for ethanol sensitivity in mice (short and long sleep) these lines of rats have very marked line differences in GABA-mediated events, and these are correlated with the sedative effects of ethanol. From these and previous studies we know that the major differences between selected lines of mice and rats are that the mouse lines are not differentially sensitive to halothane or pentobarbital white the rat lines are. However, the mouse lines are differentially sensitive to propofol and the rat lines are not. These data should be useful in dissecting the actions of ethanol at the GABA(A) receptor. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:54:50