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Titolo:
HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL RESPONSES TO PSYCHOLOGICAL STRESS AND CAFFEINE IN MEN AT HIGH AND LOW-RISK FOR HYPERTENSION
Autore:
ALABSI M; LOVALLO WR; MCKEY B; SUNG BH; WHITSETT TL; WILSON MF;
Indirizzi:
UNIV MINNESOTA,DULUTH SCH MED,DEPT BEHAV SCI DULUTH MN 55812 VET AFFAIRS MED CTR OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI OKLAHOMA CITY OK73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT MED OKLAHOMA CITY OK 73190 MILLARD FILLMORE HOSP BUFFALO NY 00000
Titolo Testata:
Psychosomatic medicine
fascicolo: 4, volume: 60, anno: 1998,
pagine: 521 - 527
SICI:
0033-3174(1998)60:4<521:HRTPS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; PARENTAL HISTORY; YOUNG MEN; NEUROENDOCRINE; REACTIVITY;
Keywords:
STRESS; CAFFEINE; HYPERTENSION; CORTISOL; ADRENOCORTICOTROPIC HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Alabsi et al., "HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL RESPONSES TO PSYCHOLOGICAL STRESS AND CAFFEINE IN MEN AT HIGH AND LOW-RISK FOR HYPERTENSION", Psychosomatic medicine, 60(4), 1998, pp. 521-527

Abstract

Objective: This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. Method: Adrenocorticotropic hormone(ACTH) and cortisol levels in plasma were assessed at rest and in response to 60-minutes of continuous work on a mental stressor (arithmetic) and a psychomotor task (reaction time) on four test sessions held on separate days. Results: Tasks alone caused greater ACTH and cortisolincreases in high risk men than in the low risk group. Caffeine aloneelevated ACTH and cortisol in both groups, with more immediate responses in the high risk group. Both groups showed significant ACTH and cortisol responses to caffeine plus tasks, with the high risk group showing more persistent elevations. The high risk group also showed the highest levels of ACTH and cortisol after caffeine plus tasks. Conclusions: These findings demonstrate for the first time the combined effectsof caffeine plus stress on ACTH and demonstrate greater corticosteroid effects in hypertension-prone men. As such, they may have implications for the dietary use of caffeine during periods of stress and in those at risk for hypertension.

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Documento generato il 23/10/20 alle ore 11:12:34