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Titolo:
EPITHELIAL-CELL PROLIFERATIVE ACTIVITY OF BARRETTS-ESOPHAGUS - METHODOLOGY AND CORRELATION WITH TRADITIONAL CANCER RISK MARKERS
Autore:
PETERS FTM; GANESH S; KUIPERS EJ; DEJAGERKRIKKEN A; KARRENBELD A; HARMS G; SLUITER WJ; KOUDSTAAL J; KLINKENBERGKNOL EC; LAMERS CBHW; KLEIBEUKER JH;
Indirizzi:
UNIV GRONINGEN HOSP,DEPT GASTROENTEROL,POB 30-001 NL-9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT ENDOCRINOL NL-9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT PATHOL NL-9700 RB GRONINGEN NETHERLANDS UNIV LEIDEN HOSP,DEPT GASTROENTEROL NL-2300 RC LEIDEN NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT GASTROENTEROL AMSTERDAM NETHERLANDS
Titolo Testata:
Digestive diseases and sciences
fascicolo: 7, volume: 43, anno: 1998,
pagine: 1501 - 1506
SICI:
0163-2116(1998)43:7<1501:EPAOB->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI; NUCLEAR ANTIGEN; GASTRIC-MUCOSA; DYSPLASIA; ADENOCARCINOMA; ERADICATION; EXPRESSION; CARCINOMA; THERAPY; BOWEL;
Keywords:
BARRETTS ESOPHAGUS; DYSPLASIA; PROLIFERATION; 5-BROMODEOXYURIDINE LABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
F.T.M. Peters et al., "EPITHELIAL-CELL PROLIFERATIVE ACTIVITY OF BARRETTS-ESOPHAGUS - METHODOLOGY AND CORRELATION WITH TRADITIONAL CANCER RISK MARKERS", Digestive diseases and sciences, 43(7), 1998, pp. 1501-1506

Abstract

Barrett's esophagus (BE) is a premalignant condition, due to chronic gastroesophageal reflux. Effective antireflux therapy may diminish cancer risk. To evaluate this option an intermediate marker is needed. Wedeveloped a methodology for measurement of epithelial cell proliferative activity of Barrett's mucosa as an intermediate marker and correlated the activity with traditional cancer risk markers and other parameters. Fifty-six patients (21-74 years of age) with Barrett's esophagusand established acid gastroesophageal reflux were included. Biopsies were taken from Barrett's mucosa at 3-cm intervals. Reflux was measured by 24-hr pH-metry. Proliferative activity was determined using in vitro labeling with 5-bromodeoxyuridine and immunohistochemistry and wasexpressed as labeling index (LI). The length of BE correlated with erect acid reflux (P = 0.002). LI in specialized columnar metaplasia washigher than in gastric metaplasia, especially in crypt epithelium (P < 0.05). Multiple regression analysis revealed independent positive correlations for surface LI with dysplasia (P 0.011), distance from the incisors (P = 0.041), and crypt LI (P = 0.000). Crypt LI showed an independent positive correlation with the length of BE (P = 0.033) and type of metaplasia (P = 0.007). In conclusion, epithelial cell proliferative activity of BE correlates with several known risk factors for cancer. Proliferative activity is an attractive intermediate marker to evaluate the effects of interventional measures to decrease cancer risk in Barrett's esophagus.

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Documento generato il 28/09/20 alle ore 16:07:24