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Titolo:
ABNORMAL INTRAGASTRIC DISTRIBUTION OF A LIQUID NUTRIENT MEAL IN PATIENTS WITH DIABETES-MELLITUS
Autore:
TRONCON LEA; ROSAESILVA L; OLIVEIRA RB; IAZIGI N; GALLO L; FOSS MC;
Indirizzi:
HOSP CLIN,DEPT CLIN MED,CAMPUS USP BR-14048900 RIBEIRAO PRET SP BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT CLIN MED SAO PAULO BRAZIL
Titolo Testata:
Digestive diseases and sciences
fascicolo: 7, volume: 43, anno: 1998,
pagine: 1421 - 1429
SICI:
0163-2116(1998)43:7<1421:AIDOAL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC MOTOR FUNCTION; AUTONOMIC NEUROPATHY; GASTROPARESIS; DYSPEPSIA; MOTILITY; STOMACH; DISORDERS; ANTRUM;
Keywords:
GASTRIC EMPTYING; INTRAGASTRIC DISTRIBUTION; GASTRIC MOTILITY; DIABETES MELLITUS; AUTONOMIC NEUROPATHY; DYSPEPSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L.E.A. Troncon et al., "ABNORMAL INTRAGASTRIC DISTRIBUTION OF A LIQUID NUTRIENT MEAL IN PATIENTS WITH DIABETES-MELLITUS", Digestive diseases and sciences, 43(7), 1998, pp. 1421-1429

Abstract

Disordered gastric motility and emptying are well known complicationsof diabetes mellitus (DM), but the pattern of intragastric distribution of food has not been extensively studied in diabetics. We examined the partition of a liquid nutrient meal between the proximal and distal stomach and the relationships between intragastric distribution of food and gastric emptying (GE) and the symptoms in DM patients with andwithout autonomic neuropathy (AN). Fourteen healthy volunteers and 20DM patients (13 with AN; 9 with dyspepsia symptoms) ingested a liquidnutrient meal (250 mi; 437 kcal) labeled with [Tc-99m]phytate. Anterior and posterior serial images of the stomach were taken for 90 min with a gamma camera. Regions of interest for the proximal and the distalhalves of the stomach and for the total gastric area were defined. Counts from each region along time allowed estimation of GE and the proportion of activity retained in the proximal stomach after meal ingestion (initial) and throughout GE (mean). GE half-times in controls (median; range: 66 min; 29-90 min) were not significantly different from diabetics (76 min; 5-->150 min, P > 0.10), but abnormal GE was found in 11 DM patients (seven delayed and four rapid). In DM patients, initialretention in the proximal stomach (42%; 16-79%) was significantly lower (P < 0.02) than in controls (55%; 44-71%). Mean retention in the proximal stomach throughout emptying also was significantly lower (P < 0.05) in DM patients (43%; 18-58%) than in controls (51%; 32-69%). There were no differences between subgroups of patients with normal, delayed, or rapid gastric emptying regarding mean meal retention in the proximal stomach. Patients with evidence of AN or with dyspepsia symptomshad significantly decreased retention of food in the proximal stomachthroughout gastric emptying. We concluded that patients with diabetesmellitus have abnormally decreased retention of gastric contents in the proximal stomach after a liquid meal, which seems to be related to the occurrence of autonomic neuropathy and dyspepsia symptoms, but notto disordered gastric emptying.

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Documento generato il 05/07/20 alle ore 09:41:11