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Titolo:
EFFECT OF AGING AND SEX ON THE [H-3]-PAROXETINE BINDING TO HUMAN PLATELETS
Autore:
MARAZZITI D; ROSSI A; PALEGO L; BARSANTI A; CARRAI M; GIANNACCINI G; SERRA P; LUCACCHINI A; CASSANO GB;
Indirizzi:
UNIV PISA,DIPARTIMENTO PSICHIATR NEUROBIOL FARMACOL & BIOTE,VIA ROMA 67 I-56100 PISA ITALY UNIV PISA,INST INTERNAL MED I-56100 PISA ITALY
Titolo Testata:
Journal of affective disorders
fascicolo: 1, volume: 50, anno: 1998,
pagine: 11 - 15
SICI:
0165-0327(1998)50:1<11:EOAASO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; SEROTONIN TRANSPORTER; )H-3>IMIPRAMINE BINDING; H-3-IMIPRAMINE BINDING; IMIPRAMINE; BRAIN; AGE; SITES; LOCALIZATION; DEPRESSION;
Keywords:
SEROTONIN; SEROTONIN TRANSPORTER; HUMAN PLATELETS; [H-3]-PAROXETINE BINDING; [H-3]-IMIPRAMINE BINDING; AGING; SEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D. Marazziti et al., "EFFECT OF AGING AND SEX ON THE [H-3]-PAROXETINE BINDING TO HUMAN PLATELETS", Journal of affective disorders, 50(1), 1998, pp. 11-15

Abstract

Since there exist conflicting results with regard to the possible effect of aging on platelet [H-3]-imipramine binding, taken as a peripheral marker of the serotonin (5-HT) transporter, we reinvestigated this matter by comparing the binding of the more selective ligand [H-3]-paroxetine in 20 aged and 23 young subjects. The results showed that neither the maximum binding capacity nor the dissociation constant (K-d) were significantly different in the two groups. When the subjects were compared according to sex, the young females revealed a statistically significant lower K-d than the males, while the contrary was true for the aged females. The K-d was significantly and negatively correlated to age in males. In addition, a significant age x gender interaction was also observed. Therefore, the sex of a subject would seem to provoke significant age-related changes in the K-d of [H-3]-paroxetine binding to platelet membranes. This might indicate modifications in the 5-HT transporter that could form the basis of a sex-related difference invulnerability to disorders, such as depression, where a dysfunction at this level is hypothesized. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:09:45