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Titolo:
CONTINUOUS COVARIABILITY OF DOPAMINE AND SEROTONIN METABOLITES IN HUMAN CEREBROSPINAL-FLUID
Autore:
GERACIOTI TD; KECK PE; EKHATOR NN; WEST SA; BAKER DG; HILL KK; BRUCE AB; WORTMAN MD;
Indirizzi:
VET AFFAIRS MED CTR,PSYCHIAT SERV,3200 VINE ST CINCINNATI OH 45220 UNIV CINCINNATI,COLL MED,DEPT PSYCHIAT CINCINNATI OH 00000
Titolo Testata:
Biological psychiatry
fascicolo: 3, volume: 44, anno: 1998,
pagine: 228 - 233
SICI:
0006-3223(1998)44:3<228:CCODAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLACTIN SECRETION; GROWTH-HORMONE; L-TRYPTOPHAN; GALACTORRHEA; STIMULATION; SERTRALINE; HEALTHY; DRUGS;
Keywords:
CEREBROSPINAL FLUID (CSF); DOPAMINE; HOMOVANILLIC ACID (HVA); HPLC; HUMAN; SEROTONIN; 5-HYDROXYINDOLEACETIC ACID (5-HIAA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Geracioti et al., "CONTINUOUS COVARIABILITY OF DOPAMINE AND SEROTONIN METABOLITES IN HUMAN CEREBROSPINAL-FLUID", Biological psychiatry, 44(3), 1998, pp. 228-233

Abstract

Background: Experiments in lower animals and humans have demonstratedthe existence of functional interactions between serotonin and dopamine in neuronal tissue. However, the relationship between parameters ofserotonin and dopamine neuronal activity over time within the centralnervous system (CNS) of the individual human has not yet been Established. Methods: We used continuous cerebrospinal fluid (CSF) sampling over 6 hours to test the hypothesis that the serotonin metabolite 5-hydroxindoleacetic acid (5-HIAA) and the dopamine metabolite homovanillicacid (HVA) significantly covary in concentration over time. Two groups of normal volunteers (total n = 16) were studied at separate hospitals and CSF was assayed for 5-HIAA and HVA hy high-performance liquid chromatography (HPLC), Three subjects underwent repeat CSF-withdrawal procedures after a 6-week interval, Results: Strong and sustained positive covariability in concentrations of HVA and 5-HIAA was observed in the CSF of individual humans. High intraindividual correlation coefficients were routinely observed; the mean intra-individual correlation coefficients were +0.897 and +0.871 in rite two normal volunteer groups. The HVA to 5-HIAA concentration ratio in CSF was 2.2 +/- 0.7 with very little variability over intervals ranging from minutes to weeks. Conclusions: The balance between CSF dopamine and serotonin metabolite concentrations remains relatively constant over time in healthy humans. Serial measures of CSF dopamine and serotonin metabolites within the same person could he an effective model in which to explore the interrelationships between these systems in various psychiatric syndromes, in response to drug treatment, and during provocative testing. Published 1998 Society of Biological Psychiatry.

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Documento generato il 25/01/20 alle ore 06:15:42