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Titolo:
NEUROPSYCHOLOGICAL RISK INDICATORS FOR SCHIZOPHRENIA - A PRELIMINARY-STUDY OF FEMALE RELATIVES OF SCHIZOPHRENIC AND BIPOLAR PROBANDS
Autore:
KREMEN WS; FARAONE SV; SEIDMAN LJ; PEPPLE JR; TSUANG MT;
Indirizzi:
UNIV CALIF DAVIS,SCH MED,DEPT PSYCHIAT,4430 V ST SACRAMENTO CA 95817 UNIV CALIF DAVIS,NAPA STATE HOSP,NAPA PSYCHIAT RES CTR NAPA CA 94558 HARVARD UNIV,MASSACHUSETTS MENTAL HLTH CTR,DEPT PSYCHIAT BOSTON MA 02115 HARVARD UNIV,INST PSYCHIAT EPIDEMIOL & GENET BOSTON MA 02115 HARVARD UNIV,BROCKTON W ROXBURY VET AFFAIRS MED CTR,DEPT PSYCHIAT BROCKTON MA 02401 MASSACHUSETTS MENTAL HLTH CTR,NEUROPSYCHOL LAB BOSTON MA 02115 HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL BOSTON MA 02115
Titolo Testata:
Psychiatry research
fascicolo: 3, volume: 79, anno: 1998,
pagine: 227 - 240
SICI:
0165-1781(1998)79:3<227:NRIFS->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPSYCHOTIC RELATIVES; AFFECTIVE-DISORDERS; UNIPOLAR DEPRESSION; MATCHING FALLACY; FOLLOW-UP; IMPAIRMENT; DEVIANCE; DEFICIT;
Keywords:
NEUROPSYCHOLOGY; RISK INDICATORS; GENETICS; MEMORY; ATTENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Kremen et al., "NEUROPSYCHOLOGICAL RISK INDICATORS FOR SCHIZOPHRENIA - A PRELIMINARY-STUDY OF FEMALE RELATIVES OF SCHIZOPHRENIC AND BIPOLAR PROBANDS", Psychiatry research, 79(3), 1998, pp. 227-240

Abstract

Evidence of subtle neuropsychological deficits in relatives of schizophrenic probands (REL-SZs) suggests that these are risk indicators forschizophrenia, but little is known about whether neuropsychological performance in REL-SZs differs from that in other groups of relatives. We compared neuropsychological function in female REL-SZs (n = 39), relatives of primarily psychotic bipolar disorder probands (REL-BPs; n =15), and a normal control group (n = 44). After adjustment for expected intellectual ability (based on reading recognition), REL-SZs showeddeficits in verbal and visual memory (Wechsler Memory Scale-Revised logical memories, visual reproductions), and auditory attention (dichotic digits) compared with either REL-BPs or control subjects. Memory, but not dichotic listening differences remained significant after adjusting for current IQ; however, average effect sizes after controlling for either reading or IQ were roughly comparable for these three parameters (d = 0.80, 0.71, and 0.69, respectively). REL-BPs and control subjects showed little difference. Although both schizophrenic and bipolar patients often manifest neuropsychological dysfunction, these preliminary findings indicate subtle neuropsychological deficits only in REL-SZs. Such differences suggest different underlying processes; neuropsychological impairment may, in part, reflect an expression of genetic liability to schizophrenia but not bipolar disorder. Replication with lager REL-BP sample and with male relatives is needed to evaluate the generalizability of the results. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 30/03/20 alle ore 13:34:13