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Titolo:
GENE-THERAPY FOR MALIGNANT PLEURAL MESOTHELIOMA
Autore:
STERMAN DH; KAISER LR; ALBELDA SM;
Indirizzi:
HOSP UNIV PENN,3600 SPRUCE ST,833 W GATES BLDG PHILADELPHIA PA 19104 UNIV PENN HLTH SYST,DEPT MED,DIV PULM & CRIT CARE PHILADELPHIA PA 00000 UNIV PENN HLTH SYST,DEPT SURG,SECT GEN THORAC SURG PHILADELPHIA PA 00000 UNIV PENN HLTH SYST,THORAC ONCOL RES LABS PHILADELPHIA PA 00000
Titolo Testata:
Hematology/oncology clinics of North America
fascicolo: 3, volume: 12, anno: 1998,
pagine: 553 -
SICI:
0889-8588(1998)12:3<553:GFMPM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENE; IN-VIVO; BRAIN-TUMORS; RETROVIRAL VECTORS; LUNG-CANCER; HSVTK GENE; ADENOVIRUS; CELLS; REGRESSION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Sterman et al., "GENE-THERAPY FOR MALIGNANT PLEURAL MESOTHELIOMA", Hematology/oncology clinics of North America, 12(3), 1998, pp. 553

Abstract

Malignant mesothelioma in (MM) is a fatal malignancy refractory to all forms of standard anticancer therapy. This article reports the results of a phase I clinical trial assessing the safety of intrapleural delivery and efficacy of intratumoral gene transfer of recombinant adenovirus (rAd) containing herpes simplex virus thymidine kinase (HSVtk) gene into the pleural space of patients with MM, followed by systematictreatment with the antiviral drug ganciclovir, ir (GCV) for 14 days. A D.RSVtk/GCV gene therapy proved to be well tolerated with evidence of significant gene transfer particularly at high vector doses and withelimination of preliminary biopsy. Ongoing gene therapy trials for mesothelioma at two other centers, focusing on immunostimulation and using suicide gene therapy as a tumor vaccine, are also reviewed in this article.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 11:45:10