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Titolo:
INFLUENCE OF CERVICAL SYMPATHETIC-NERVES ON VENTILATION AND UPPER AIRWAY-RESISTANCE IN THE RAT
Autore:
OHALLORAN KD; CURRAN AK; BRADFORD A;
Indirizzi:
ROYAL COLL SURGEONS IRELAND,DEPT PHYSIOL,ST STEPHENS GREEN DUBLIN 2 IRELAND ROYAL COLL SURGEONS IRELAND,DEPT PHYSIOL DUBLIN 2 IRELAND UNIV WISCONSIN,SCH VET MED,DEPT COMPARAT BIOSCI MADISON WI 53706 UNIV WISCONSIN,DEPT PREVENT MED MADISON WI 53706
Titolo Testata:
The European respiratory journal
fascicolo: 1, volume: 12, anno: 1998,
pagine: 177 - 184
SICI:
0903-1936(1998)12:1<177:IOCSOV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENIOHYOID MUSCLE-ACTIVITY; CAROTID-BODY; INSPIRATORY ACTIVITY; STIMULATION; RESPONSES; NASAL; CAT; SECRETION; DIAPHRAGM; PATHWAYS;
Keywords:
AIRWAY RESISTANCE; ALPHA-ADRENOCEPTOR; BETA-ADRENOCEPTOR; CERVICAL SYMPATHETIC NERVE; CONTROL OF BREATHING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Ohalloran et al., "INFLUENCE OF CERVICAL SYMPATHETIC-NERVES ON VENTILATION AND UPPER AIRWAY-RESISTANCE IN THE RAT", The European respiratory journal, 12(1), 1998, pp. 177-184

Abstract

The cervical sympathetic trunks innervate the carotid bodies, carotidbaroreceptors, thyroid gland and the upper airway mucosa, structures which can influence breathing and upper airway resistance. However, their role in the control of ventilation and upper airway patency is poorly understood. A constant airflow was applied to the upper airway through a high-cervical tracheostomy in anaesthetized rats breathing spontaneously through a low-cervical tracheostomy, The peripheral ends of the cut cervical sympathetic trunks were stimulated electrically and airflow resistance and ventilation were measured. The effects of cervical sympathetic trunk section on ventilation were also measured in conscious rats. In conscious rats, cutting the sympathetic trunks caused adecrease in ventilation during normoxia but only slightly affected ventilatory responses to hypoxia and hypercapnia. In anaesthetized rats,sympathetic trunk stimulation caused an inhibition of breathing whichwas sometimes followed by excitation. These responses were unaffectedby alpha- or beta-adrenoceptor blockade but were abolished by cuttingthe carotid sinus nerves. Sympathetic stimulation also caused a fall in upper airway resistance which was reduced by bypassing the nose, unaffected by propranolol or carotid sinus nerve section and abolished by phentolamine, It was concluded that the cervical sympathetic nerves exert important influences on ventilation and upper airway resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:18:36