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Titolo:
CORRELATION BETWEEN BCL-X EXPRESSION AND B-CELL HYBRIDOMA APOPTOSIS INDUCED BY ACTIVIN-A
Autore:
KOSEKI T; YAMATO K; ISHISAKI A; HASHIMOTO O; SUGINO H; NISHIHARA T;
Indirizzi:
NATL INST INFECT DIS,DEPT ORAL SCI,SHINJUKU KU,1-23-1 TOYAMA TOKYO 162 JAPAN NATL INST INFECT DIS,DEPT ORAL SCI,SHINJUKU KU TOKYO 162 JAPAN TOKYO MED & DENT UNIV,FAC DENT,DEPT MOL & CELLULAR ONCOL MICROBIOL,BUNKYO KU TOKYO 113 JAPAN UNIV TOKUSHIMA,INST ENZYME RES TOKUSHIMA 770 JAPAN
Titolo Testata:
Cellular signalling
fascicolo: 7, volume: 10, anno: 1998,
pagine: 517 - 521
SICI:
0898-6568(1998)10:7<517:CBBEAB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN KINASE-C; THYMOCYTE APOPTOSIS; DEATH; SURVIVAL; IDENTIFICATION; PURIFICATION; MACROPHAGES; INVOLVEMENT; HOMOLOG; GENE;
Keywords:
ACTIVIN; APOPTOSIS; BCL-XL; BCL-XS; BCL-2; PROTEIN KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Koseki et al., "CORRELATION BETWEEN BCL-X EXPRESSION AND B-CELL HYBRIDOMA APOPTOSIS INDUCED BY ACTIVIN-A", Cellular signalling, 10(7), 1998, pp. 517-521

Abstract

In this study, we examined the role of bcl-XL and bcl-Xs in apoptoticcell death of HS-72 cells induced by activin A. Immunoblot analysis revealed that a band of Bcl-XL was detected in HS-72 cells cultured with or without activin A. Although untreated HS-72 cells did not expressBcl-Xs, the expression of Bcl-Xs was significantly increased when cultured with activin A. We also investigated the expression of Bcl-Xs and Bcl-XL in HS-72 cells cultured with activin A in the presence of protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H7), which suppressed apoptosis in HS-72 cells induced by activin A. Ex posure to H7 apparently increased the level of Bcl-XL in HS-72 cells cultured with or without activin A. In contrast, no detectable band of Bcl-Xs was found in HS-72 cells cultured with activin A and H7. These findings indicate that Bcl-XL upregulation and Bcl-Xs downregulation induced by H7 might correlate with the suppression of activin A-induced apoptosis in B-lineage cells. CELL SIGNAL 10;7:511-521, 1998. (C) 1998 Elsevier Science Inc.

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Documento generato il 24/11/20 alle ore 11:20:44