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Titolo:
EFFECTS OF NEBULIZED NITROPRUSSIDE ON PULMONARY AND SYSTEMIC HEMODYNAMICS DURING PULMONARY-HYPERTENSION IN PIGLETS
Autore:
MEADOW W; RUDINSKY B; BELL A; HIPPS R;
Indirizzi:
UNIV CHICAGO,DEPT PEDIAT,MC 6060,5825 S MARYLAND AVE CHICAGO IL 60637 UNIV CHICAGO,CHILDRENS HOSP,DEPT PEDIAT CHICAGO IL 60637
Titolo Testata:
Pediatric research
fascicolo: 2, volume: 44, anno: 1998,
pagine: 181 - 186
SICI:
0031-3998(1998)44:2<181:EONNOP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED NITRIC-OXIDE; ENDOTHELIUM-DEPENDENT RELAXATION; B STREPTOCOCCAL SEPSIS; RESPIRATORY-DISTRESS; RELAXING FACTOR; NEWBORN PIGLET; TOLAZOLINE; NITROGLYCERIN; EPINEPHRINE; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
W. Meadow et al., "EFFECTS OF NEBULIZED NITROPRUSSIDE ON PULMONARY AND SYSTEMIC HEMODYNAMICS DURING PULMONARY-HYPERTENSION IN PIGLETS", Pediatric research, 44(2), 1998, pp. 181-186

Abstract

We tested the effects of nebulized nitroprusside (Neb-NP) on pulmonary and systemic hemodynamics during pulmonary hypertension induced by hypoxia or group B streptococci infusion in piglets. Twenty-three anesthetized and mechanically ventilated piglets received Neb-NP under fourexperimental conditions: 1) normoxia; 2) 15 and 60 min of pulmonary hypertension induced by hypoxia; 3) after pretreatment with dipyridamole; 4) pulmonary hypertension induced by infusion of group B streptococci. In addition, Neb-NP was contrasted to nebulization of tolazoline. During hypoxia-induced pulmonary hypertension, Neb-NP significantly reduced pulmonary artery pressure [PAP; -8.4 +/- 0.9 (SEM) mm Hg] and pulmonary vascular resistance (-25 +/- 2.1%) (both p < 0.001), whereas neither systemic arterial pressure nor cardiac output changed significantly. Selective pulmonary vasodilation began within 2 min of the onsetof Neb-NP, and did not wane over 1 h. In contrast, within 5 min afterNeb-NP was discontinued while hypoxia persisted, PAP rose significantly. Pretreatment with dipyridamole did not enhance the pulmonary vasodilation induced by Neb-NP, but did reduce systemic arterial pressure. Nebulized tolazoline did not reduce PAP significantly, but did lower systemic arterial pressure. Selective pulmonary vasodilation induced byNeb-NP was significantly smaller during group B streptococci-induced versus hypoxia-induced pulmonary hypertension. In sum, Neb-NP producedprompt, significant, selective reduction of PAP in piglets with pulmonary hypertension. Cautious extrapolation of these findings to selected clinical conditions in human infants may be warranted.

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Documento generato il 31/03/20 alle ore 10:09:30