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Titolo:
ENTORHINAL CORTEX OF THE RAT - TOPOGRAPHIC ORGANIZATION OF THE CELLS OF ORIGIN OF THE PERFORANT PATH PROJECTION TO THE DENTATE GYRUS
Autore:
DOLORFO CL; AMARAL DG;
Indirizzi:
UNIV CALIF DAVIS,CTR NEUROSCI,DEPT PSYCHIAT,1544 NEWTON COURT DAVIS CA 95616 UNIV CALIF DAVIS,CTR NEUROSCI,DEPT PSYCHIAT DAVIS CA 95616 UNIV CALIF DAVIS,CALIF REG PRIMATE RES CTR DAVIS CA 95616 UNIV CALIF SAN DIEGO,NEUROSCI GRP LA JOLLA CA 92193 HUNGARIAN ACAD SCI,INST EXPT MED,DEPT FUNCT ANAT H-1450 BUDAPEST HUNGARY
Titolo Testata:
Journal of comparative neurology
fascicolo: 1, volume: 398, anno: 1998,
pagine: 25 - 48
SICI:
0021-9967(1998)398:1<25:ECOTR->2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL-FORMATION; EFFERENT CONNECTIONS; SEPTOTEMPORAL AXIS; DIAMIDINO YELLOW; FASCIA DENTATA; ADULT-RAT; BRAIN; SUBICULUM; MONKEY; INJECTION;
Keywords:
HIPPOCAMPUS; FAST BLUE; DIAMIDINO YELLOW; PARVALBUMIN; 3-DIMENSIONAL RECONSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Dolorfo e D.G. Amaral, "ENTORHINAL CORTEX OF THE RAT - TOPOGRAPHIC ORGANIZATION OF THE CELLS OF ORIGIN OF THE PERFORANT PATH PROJECTION TO THE DENTATE GYRUS", Journal of comparative neurology, 398(1), 1998, pp. 25-48

Abstract

By using three-dimensional computer reconstruction techniques and theproduction of two-dimensional unfolded maps, we analyzed the topographic organization of projections from the entorhinal cortex of the rat to the dentate gyrus. The retrograde tracers, Fast blue and Diamidino yellow, were injected at all septotemporal levels of the dentate gyrus, and the distribution of retrogradely labeled layer II cells in the entorhinal cortex was plotted by using computer-aided microscopy systems. Discrete injections of fluorescent dyes into the dentate gyrus labeled bands of layer II neurons in the entorhinal cortex that covered approximately 45% of its surface area. Injections confined to the septalhalf of the dentate gyrus resulted in a band that occupied the most lateral and caudomedial portions of the entorhinal cortex. Although there were subtle changes in the density of labeled cells in this region,essentially the same region of cells was labeled after any injection into the septal half of the dentate gyrus. Injections into mid-septotemporal levels of the dentate gyrus (50-75% of the distance from the septal pole) led to a distinctly different pattern of retrograde labeling. A more medial portion of the lateral entorhinal cortex and a more rostral portion of the medial entorhinal area were labeled in these cases. Another change in entorhinal labeling occurred when the injection involved the most temporal quarter of the dentate gyrus. Injections into this area led to a constrained region of entorhinal labeling that included the most medial portion of the lateral entorhinal area and themost rostral portion of the medial entorhinal area. Although the domains of cells projecting to septal, mid-septotemporal, and temporal levels of the dentate gyrus were not entirely segregated, there was relatively little overlap of the three populations of neurons. These data raise the possibility that different portions of the entorhinal-hippocampal circuit are capable of semiautonomous information processing, at least at the stage of input to the dentate gyrus. J. Comp. Neurol. 398:25-48, 1998. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 20/01/20 alle ore 07:36:55