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Titolo:
RETT-SYNDROME, EEG AND THE MOTOR CORTEX AS A MODEL FOR BETTER UNDERSTANDING OF ATTENTION-DEFICIT HYPERACTIVITY DISORDER (ADHD)
Autore:
NIEDERMEYER E; NAIDU SB;
Indirizzi:
KENNEDY KRIEGER INST,707 N BROADWAY BALTIMORE MD 21287 KENNEDY KRIEGER INST BALTIMORE MD 21287 JOHNS HOPKINS UNIV HOSP BALTIMORE MD 21287
Titolo Testata:
European child & adolescent psychiatry
fascicolo: 2, volume: 7, anno: 1998,
pagine: 69 - 72
SICI:
1018-8827(1998)7:2<69:REATMC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMALITIES; CHILDREN;
Keywords:
RETT SYNDROME; EEG; MOTOR CORTEX DYSCONTROL; FRONTAL LOBE; FRONTAL MOTOR CORTEX UNCOUPLING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
E. Niedermeyer e S.B. Naidu, "RETT-SYNDROME, EEG AND THE MOTOR CORTEX AS A MODEL FOR BETTER UNDERSTANDING OF ATTENTION-DEFICIT HYPERACTIVITY DISORDER (ADHD)", European child & adolescent psychiatry, 7(2), 1998, pp. 69-72

Abstract

EEG data in Rett syndrome (RS) are quite often characterized by spikes over the central region (especially in sleep). Furthermore, there has been a recent observation of a prominent and peculiar theta (4-6/s) rhythm over the central region and vicinity. In view of the clinical phenomena of RS, it is pointed out that clinical and electrical findings are based upon hyperexcitability of the motor cortex (or a state of motor cortex dyscontrol). States of dyscontrol (disinhibition) are caused by deficits in higher cortical functions. It is reasonable to assume a primary dysfunction for the frontal lobe which is also smaller insize than other cerebral regions.The behavioral (motor) disturbance in RS can be easily explained as the expression of disturbed prefrontal/premotor function with special effect on the ''syntax of action''. Itis further theorized that such a state of fronto-motor cortex uncoupling may also exist in attention deficit hyperkinetic disorder (ADHD) even though there is hardly any structural CNS impairment in that condition. A presumed ''lazy frontal lobe'' is likely to react favorably tothe stimulation provided by methylphenidate (a therapeutic effect which should not be viewed as paradoxical).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:19:11