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Titolo:
EFFECT OF HEART-TRANSPLANTATION ON IMPAIRED PERIPHERAL MICROVASCULAR PERFUSION AND REACTIVITY IN CONGESTIVE-HEART-FAILURE
Autore:
ANDREASSEN AK; KIRKEBOEN KA; GULLESTAD L; SIMONSEN S; KVERNEBO K;
Indirizzi:
NATL HOSP NORWAY,DEPT CARDIOL OSLO NORWAY UNIV OSLO,ULLEVAL HOSP,DEPT ANESTHESIA N-0316 OSLO NORWAY UNIV OSLO,ULLEVAL HOSP,EXPT MED RES INST N-0316 OSLO NORWAY UNIV OSLO,ULLEVAL HOSP,DEPT SURG N-0316 OSLO NORWAY
Titolo Testata:
International journal of cardiology
fascicolo: 1, volume: 65, anno: 1998,
pagine: 33 - 40
SICI:
0167-5273(1998)65:1<33:EOHOIP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER DOPPLER FLOWMETRY; TISSUE BLOOD-FLOW; NITRIC-OXIDE; CARDIAC TRANSPLANTATION; ENDOTHELIAL FUNCTION; CYCLOSPORINE; SKIN; VESSELS; HYPERTENSION; VASODILATION;
Keywords:
CONGESTIVE HEART FAILURE; HEART TRANSPLANTATION; PERIPHERAL MICROCIRCULATION; LASER DOPPLER PERFUSION MEASUREMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Andreassen et al., "EFFECT OF HEART-TRANSPLANTATION ON IMPAIRED PERIPHERAL MICROVASCULAR PERFUSION AND REACTIVITY IN CONGESTIVE-HEART-FAILURE", International journal of cardiology, 65(1), 1998, pp. 33-40

Abstract

Whether reduced peripheral blood flow in congestive heart failure is reversed after heart transplantation, has not been closely examined. We therefore studied skin microvascular resting perfusion and reactivity in patients pre- and postoperatively. Resting digital skin perfusion, together with the responses to cold presser test, postocclusive reactive hyperemia and direct skin heating were examined with laser Doppler perfusion measurements. We examined 28 patients with congestive heart failure and 14 of these patients after heart transplantation and compared them to 13 healthy controls. Measurements were performed within 3 months preoperatively and 12 days, 1, 2, 3 and 6 months postoperatively. Patients with congestive heart failure had significantly lower resting perfusion levels than controls and demonstrated attenuated responses to both stimuli of vasodilation (all P<0.01). While peak hyperemic responses improved significantly after transplantation, postocclusive area under the hyperemic curve decreased further, and none of these variables were normalized after 6 months. In contrast, minimal perfusion during cold presser test increased from a significantly lower levelin the patients with congestive heart failure (P<0.05), to a level similar to that of the controls within 12 days postoperatively. Thus, skin microvascular perfusion and reactivity improve, but are not normalized within 6 months of transplantation. Both pre- and postoperative factors may be involved in maintaining a dysfunction of the peripheral microcirculation, which may contribute to exercise intolerance and hypertension in heart transplant recipients. (C) 1998 Elsevier Science Ireland Ltd.

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Documento generato il 22/09/20 alle ore 08:09:24