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Titolo:
QUANTITATIVE TRAIT LOCI DISPOSING FOR BOTH EXPERIMENTAL ARTHRITIS ANDENCEPHALOMYELITIS IN THE DA RAT - IMPACT ON SEVERITY OF MYELIN OLIGODENDROCYTE GLYCOPROTEIN-INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND ANTIBODY ISOTYPE PATTERN
Autore:
DAHLMAN I; LORENTZEN JC; DEGRAAF KL; STEFFERL A; LININGTON C; LUTHMAN H; OLSSON T;
Indirizzi:
KAROLINSKA HOSP,DEPT MED,NEUROIMMUNOL UNIT S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MED,RHEUMATOL UNIT S-17176 STOCKHOLM SWEDEN MAX PLANCK INST PSYCHIAT,DEPT NEUROIMMUNOL MARTINSRIED GERMANY KAROLINSKA HOSP,DEPT MOL MED,ROLF LUFT CTR DIABET RES S-17176 STOCKHOLM SWEDEN
Titolo Testata:
European Journal of Immunology
fascicolo: 7, volume: 28, anno: 1998,
pagine: 2188 - 2196
SICI:
0014-2980(1998)28:7<2188:QTLDFB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; RECEPTOR-BETA-CHAIN; INTERFERON-GAMMA SECRETION; MESSENGER-RNA EXPRESSION; CENTRAL-NERVOUS-SYSTEM; T-CELL CLONES; MULTIPLE-SCLEROSIS; GENETIC-ANALYSIS; LEWIS RATS; RHEUMATOID-ARTHRITIS;
Keywords:
MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TH1; TH2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
I. Dahlman et al., "QUANTITATIVE TRAIT LOCI DISPOSING FOR BOTH EXPERIMENTAL ARTHRITIS ANDENCEPHALOMYELITIS IN THE DA RAT - IMPACT ON SEVERITY OF MYELIN OLIGODENDROCYTE GLYCOPROTEIN-INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND ANTIBODY ISOTYPE PATTERN", European Journal of Immunology, 28(7), 1998, pp. 2188-2196

Abstract

Quantitative trail loci (QTL) controlling inflammatory diseases with different organ specificity may hypothetically either be unique for one disease or shared among different diseases. We have investigated whether five non-MHC QTL controlling susceptibility to experimental arthritis in the DA rat also influence myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in an F2intercross between inbred DA and PVG.RT1(a) rats. Two of the five chromosome regions affecting arthritis in the DA rat also regulate phenotypes of EAE. The DA allele at markers in Cia3 (collagen-induced arthritis QTL) on chromosome 4 is associated with more severe EAE and high levels of anti-MOG antibodies of the IgG2c subclass. Since production of antibodies of the IgG2c subclass may be stimulated by Th1 cells, andthere is previous evidence that such cells promote EAE, it is possible that both of the studied phenotypes are controlled by the same gene or genes regulating Th1-Th2 cell differentiation. Furthermore, we showthat Oia2 (oil-induced arthritis QTL) on chromosome 4 regulates levels of anti-MOG antibodies of the IgG1 subclass and of anti-MOG IgE, butthat this gene region does not affect clinical disease severity in our study. Since production of IgE and IgG1 may be stimulated by Th2 cells, this QTL may also control Th1/Th2 bias. We conclude that Cia3 and Oia2 regulate MOG-induced EAE in rats. Furthermore, since both EAE andarthritis phenotypes co-localize to these gene regions, they may harbor genes which are key regulators of pathogenic immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:15:57