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Titolo:
INTERFERON REGULATORY FACTOR-I IS A MAJOR REGULATOR OF EPIDERMAL GROWTH-FACTOR RECEPTOR GENE-EXPRESSION
Autore:
RUBINSTEIN YR; PROCTOR KN; BERGEL M; MURPHY B; JOHNSON AC;
Indirizzi:
NCI,MOL BIOL LAB,DIV BASIC SCI,BLDG 37,ROOM 2D18,37 CONVENT DR,MSC-4255 BETHESDA MD 20892 NCI,MOL BIOL LAB,DIV BASIC SCI BETHESDA MD 20892 NCI,MOL CARCINOGENESIS LAB,DIV BASIC SCI BETHESDA MD 20892
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 431, anno: 1998,
pagine: 268 - 272
SICI:
0014-5793(1998)431:2<268:IRFIAM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
IFN-INDUCIBLE GENES; BREAST-CANCER; CELL-LINE; FACTOR-I; TRANSCRIPTION FACTOR; ALPHA-INTERFERON; EGF RECEPTOR; IRF-1; BETA; ACTIVATION;
Keywords:
EPIDERMAL GROWTH FACTOR RECEPTOR; PROMOTER; GENE REGULATION; INTERFERON; DNA BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y.R. Rubinstein et al., "INTERFERON REGULATORY FACTOR-I IS A MAJOR REGULATOR OF EPIDERMAL GROWTH-FACTOR RECEPTOR GENE-EXPRESSION", FEBS letters, 431(2), 1998, pp. 268-272

Abstract

Overexpression of the epidermal growth factor receptor (EGFR) occurs in many; tumors and in breast cancer correlates with poor prognosis for treatment. Here, we report that interferon regulatory factor-1 (IRF-1) induces EGFR promoter activity up to 200-fold compared to 3-10-foldinduction by other regulators. The region of the promoter that is required for this induction was defined using deletion mutants. In addition, we found that IRF-1 and tricostatin A, a deacetylase inhibitor, have a synergistic effect on EGFR promoter activity. This indicates thatthe increase in EGFR promoter activity by IRF-1 may also involve changes in chromatin structure. These results identify IRF-1 as a major regulator of EGFR gene expression. (C) 1998 Federation of European Biochemical Societies.

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Documento generato il 04/04/20 alle ore 21:18:06