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Titolo:
EFFECTS OF MOLYBDATE ON THE SULFATION OF HARMOL AND ALPHA-NAPHTHOL
Autore:
BOLES JW; KLAASSEN CD;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,CTR ENVIRONM &OCCUPAT HLTH KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,CTR ENVIRONM &OCCUPAT HLTH KANSAS CITY KS 66160
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 127, anno: 1998,
pagine: 121 - 127
SICI:
0300-483X(1998)127:1-3<121:EOMOTS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE; PERFUSED-RAT-LIVER; INORGANIC SULFATE; ACETAMINOPHEN; CONJUGATION; INVIVO; IMPAIRS; ACID;
Keywords:
MOLYBDATE; HARMOL; ALPHA-NAPHTHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Boles e C.D. Klaassen, "EFFECTS OF MOLYBDATE ON THE SULFATION OF HARMOL AND ALPHA-NAPHTHOL", Toxicology, 127(1-3), 1998, pp. 121-127

Abstract

Sulfation requires the activity of sulfotransferases to transfer the sulfuryl group to the substrate from the activated form of sulfate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Inhibition of the sulfate reaction is an important aspect in evaluating the role of sulfation intoxicology. Molybdate decreases hepatic PAPS and its precursor, inorganic sulfate, and could be used as a tool to inhibit the sulfation reaction. The present study was designed to determine the effect of molybdate on the sulfation of two compounds (harmol and alpha-naphthol), for which sulfation is the predominate pathway of biotransformation. Molybdate (7.5 mmol/kg; p.o.) given 4 h prior to the start of harmol infusion (2.5 mu mol/kg/min) decreased serum harmol-sulfate concentrationsby 32 and 45%, at 45 and 60 min, respectively. This was paralleled bydecreases in the cumulative biliary excretion of harmol-sulfate of 37and 43%, at 45 and 60 min, respectively. Molybdate (5.0 mmol/kg, p.o.) decreased the 24-h cumulative urinary excretion of naphthyl-sulfate by 55% for a 125-mu mol/kg i.p. dose of alpha-naphthol, with the greatest decrease (63%) occurring during the first 4 h. These results suggest that molybdate can inhibit the sulfation of compounds that are highly sulfated. Thus, molybdate may prove useful in future studies to examine the pharmacological and toxicological significance of sulfation of xenobiotics. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:33:42